VIOLENT BEHAVIOR, NEUROTRANSMITTERS, GLUCOSE METABOLISM, AND ALCOHOL ABUSE

暴力行为、神经递质、葡萄糖代谢和酒精滥用

• 批准号: 3801952
• 负责人: M LINNOILA
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3801952
• 关键词: aggression; alcoholism /alcohol abuse; cerebrospinal fluid; criminology; glucose metabolism; glucose tolerance test; human subject; hydroxyindoleacetate; hypoglycemia; interview; lymphocyte; molecular genetics; neuropsychology; neurotransmitter metabolism; violence

We have investigated neurotransmitter metabolites and glucose metabolism in incarcerated violent offenders, arsonists and healthy volunteers. We have found that low cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5HIAA) concentrations and hypoglycemia during oral glucose tolerance tests are associated with each other and impulsive violent acts and fire setting. In a follow-up study, we found that a low blood glucose nadir and low CSF 5HIAA concentration were powerful predictors of recidivism among impulsive violent offenders and fire setters. We are currently collecting lymphocytes for molecular genetic studies from violent offenders, their family members and appropriate controls.

我们研究了神经递质代谢物和葡萄糖代谢， 被监禁的暴力罪犯纵火犯和健康志愿者 我们有 发现低脑脊液（CSF），5-羟基吲哚乙酸 口服葡萄糖耐量试验期间的（5 HIAA）浓度和低血糖 与冲动暴力行为和纵火有关。 在一项随访研究中，我们发现低血糖最低点和低CSF 5 HIAA浓度是冲动型再犯罪的有力预测因素 暴力犯罪者和纵火犯。 我们目前正在收集 淋巴细胞的分子遗传学研究，从暴力罪犯，他们的 家庭成员和适当的控制。