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BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER

BIOCHEMICAL MODULATION OF 5-FLUOROURACIL AND LEUCOVORIN IN COLORECTAL CANCER
5-氟尿嘧啶和亚叶酸在结直肠癌中的生化调节
批准号：
3744951
负责人：
HYMAN MUSS
金额：
$0.0万
依托单位：
WAKE FOREST UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3744951
关键词：
N phosphonoacetyl L aspartate colorectal neoplasms combination chemotherapy drug resistance drug screening /evaluation fluorouracil human subject human therapy evaluation leucovorin neoplasm /cancer chemotherapy

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英文摘要
The development or resistance to anti-cancer drugs is the principal cause of chemotherapy failure in cancer patients. The goal of this study is to increase the response to the anti-cancer agent 5-fluorouracil by overcoming tumor cell resistance with a second anti-cancer agent PALA. This study uses a 3X3 factorial design to assess the joint effects of PALA, leucovorin and fluorouracil on various biochemical endpoints in patients with resectable colorectal cancer. The results will provide a basis for improving therapy.
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