CANCER CENTER CALGB PARTICIPATION
癌症中心 CALGB 参与
基本信息
- 批准号:6376690
- 负责人:
- 金额:$ 14.52万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-04-20 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS related neoplasm /cancer aging antineoplastics bone marrow transplantation breast neoplasms cancer prevention cancer registry /resource carmustine chemoprevention cis platinum compound clinical research clinical trials combination cancer therapy combination chemotherapy cooperative study cyclophosphamide doxorubicin drug resistance finasteride fluorouracil gastrointestinal neoplasms health care cost /financing hormone therapy human genetic material tag human subject human therapy evaluation interleukin 2 leucovorin leukemia lymphoma melanoma neoplasm /cancer chemotherapy neoplasm /cancer diagnosis neoplasm /cancer epidemiology neoplasm /cancer genetics neoplasm /cancer immunotherapy neoplasm /cancer radiation therapy neoplasm /cancer surgery neoplasm /cancer vaccine oncology nursing paclitaxel pathology prostate neoplasms psychology quality of life respiratory neoplasm tamoxifen tissue resource /registry weight loss
项目摘要
DESCRIPTION (adapted from the applicant's abstract): The Vermont Cancer
Center (VCC), an NCI designated Comprehensive Cancer Center, joined the
CALGB in 1995. In that short time the VCC has made significant headway in
becoming a major participant in CALGB activities. Eight VCC members have
made major commitments to supporting CALGB efforts. Dr. Hyman Muss
continues to be extremely active in CALGB and serves as the Co-Chair of the
Working Group for the Elderly and the Vice Chair of the Breast Cancer
Committee, in addition to chairing two CALGB protocols (8869 and 9670). Dr.
Steven Grunberg, a member of the Clinical Economics Committee, is currently
developing a clinical protocol that will compare cost with symptom control
for antiemetics. Dr. David Krag is an active member of the Breast Core
Committee and is helping CALBG develop a protocol for sentinel node staging
for women with early stage breast cancer. Dr. Seth Harlow will assume Dr.
Krag's role as member of the Surgery Committee. Dr. Donald Weaver
participates extensively in pathology group activities and has a major
interest in breast cancer. Drs. Michael Cooper, Barbara Grant, and Richard
Branda have major interest in urologic cancer, leukemia and lymphoma, and
nutrition and cancer, respectively, and have developed concepts for CALGB
clinical investigations. The development of multidisciplinary, disease-site
oriented, affinity groups within our Center has established major liaisons
between laboratory and clinical scientists. This will strengthen our
institutional commitment to the group and allow VCC members to develop
innovative companion trials for the CALGB. Recently, Drs. Grant and Branda
presented two concepts-one related to assessing the importance of folate
status on chemotherapy toxicity in women with early breast cancer, and a
second that utilizes a novel reporter gene (hprt) to monitor and possibly
define women with early stage breast cancer who might be at high risk for
developing secondary acute nonlymphocytic leukemia. Drs. Weaver and other
VCC scientists are drafting a concept that will explore the role of erbB-2
associated signaling proteins as mediators of apoptosis for women with early
stage breast cancer treated with anthracyclines (CALGB 8541). We anticipate
a major increase in accrual in the next year. The Green Mountain Oncology
Group (CCOP) selected the VCC as its research base beginning in April, 1997.
In one month they have entered 10 patients on CALGB protocols. Two new
faculty will join the VCC this summer who have major interests in genetics
and high-dose therapy; it is anticipated they will be active in CALGB
activities. Also, we are developing a major outreach program and expect to
add several affiliates with interest in clinical trials. In addition, we
have developed a high-dose chemotherapy autologous stem cell support program
and expect to become a CALGB Transplant Center by the start of the next
funding period.
描述(改编自申请人摘要):佛蒙特州癌症
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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HYMAN MUSS其他文献
HYMAN MUSS的其他文献
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{{ truncateString('HYMAN MUSS', 18)}}的其他基金
Biomarkers of Molecular Age to Predict the Toxicity of Cancer Chemotherapy
分子年龄的生物标志物可预测癌症化疗的毒性
- 批准号:
9205493 - 财政年份:2016
- 资助金额:
$ 14.52万 - 项目类别:
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