CORE--NEUROPATHOLOGY

阿尔茨海默病研究需要广泛的神经病理学支持 服务。临床核心的临床医生需要知道是否给出了 个人患有阿尔茨海默氏症或其他令人眩晕的疾病。因此， 需要对登记的患者和对照进行尸检随访 临床诊断和治疗试验。此外，对于基因 家族性阿尔茨海默病的研究和尸检确诊 无论是临床影响还是临床正常，最终都需要 家庭成员。还需要“外展”方案，以提供 为痴呆症患者及其家人提供诊断服务 社区。此外，由于没有被广泛接受的动物模型 对于这种毁灭性的疾病，研究人员需要人脑组织来 实验生化、分子生物学和组织学研究。 因此，神经病理核心被设计成满足三个方面 明确的目标。首先，将在30-60分钟内获得新鲜的脑组织 在死亡后几分钟通过快速尸检程序，一个独特的功能 这个中心。其次，凯瑟琳·普莱斯·布莱恩大脑银行的工作人员将 获取标本、建立病理诊断、解剖和存储 痴呆症患者和对照组患者的脑组织，并将样本释放到 合格的调查员。第三，智库将协调一条路线 为组织学、神经病理学和神经化学数据提供服务。作为一部分 在这个数据管理功能中，大脑银行将协调其数据- 与研究临床核心中心的活动一起收集。

Alzheimer's disease research requires extensive neuropathology support services. Clinicians in the Clinical Core need to know whether a given individual had Alzheimer's disease or some other dementing illness. Thus, autopsy follow-up is needed on patients and controls enrolled in the clinical diagnosis and therapeutic trials. In addition, for genetic studies of familial Alzheimer's disease, definitive post-mortem diagnoses are eventually required for both clinically affected and clinically normal family members. There is also a need for "outreach" programs providing diagnostic services for demented patients and their families in the community. In addition, since there are no widely accepted animal modes for this devastating illness, researchers require human brain tissue for experimental biochemical, molecular biological, and histological studies. The Neuropathology Core ha therefore been designed to fulfill three specific aims. First, fresh brain tissue will be obtained within 30-60 minutes after death through the Rapid Autopsy Program, a unique feature of this Center. Second, the Staff of the Kathleen Price Bryan Brain Bank will acquire specimens, establish pathological diagnoses, dissect and store brain tissue from demented and control patients, and release specimens to qualified investigators. Third, the Brain Bank will coordinate a routing service for histological neuropathological and neurochemical data. As part of this data management function, the Brain Bank will coordinate its data- gathering activities with those of the Research Clinical Core.