CORE--NEUROPATHOLOGY

阿尔茨海默病研究需要广泛的神经病理学支持 服务 临床中心的临床医生需要知道给定的 个体患有阿尔茨海默氏病或其他痴呆疾病。 因此，在本发明中， 需要对入组的患者和对照组进行尸检随访， 临床诊断和治疗试验。 此外，对于遗传 家族性阿尔茨海默病的研究，明确的死后诊断， 最终需要临床受累和临床正常 家庭成员 还需要“推广”方案， 为区内痴呆症患者及其家属提供的诊断服务 社区 此外，由于没有广泛接受的动物模式， 对于这种毁灭性的疾病，研究人员需要人脑组织， 实验生物化学、分子生物学和组织学研究。 因此，神经病理学核心旨在实现三个 具体目标。 首先，新鲜脑组织将在30-60 通过快速尸检程序，一个独特的功能， 这个中心。 第二，Kathleen Price Bryan Brain Bank的工作人员将 采集标本，建立病理诊断，解剖和储存 从痴呆症患者和对照组患者的脑组织，并释放标本， 合格的调查员。 第三，脑库将协调一个路由， 组织学、神经病理学和神经化学数据服务。 一部分 在数据管理功能中，脑库将协调其数据- 与临床研究中心的活动一起收集活动。

Alzheimer's disease research requires extensive neuropathology support services. Clinicians in the Clinical Core need to know whether a given individual had Alzheimer's disease or some other dementing illness. Thus, autopsy follow-up is needed on patients and controls enrolled in the clinical diagnosis and therapeutic trials. In addition, for genetic studies of familial Alzheimer's disease, definitive post-mortem diagnoses are eventually required for both clinically affected and clinically normal family members. There is also a need for "outreach" programs providing diagnostic services for demented patients and their families in the community. In addition, since there are no widely accepted animal modes for this devastating illness, researchers require human brain tissue for experimental biochemical, molecular biological, and histological studies. The Neuropathology Core ha therefore been designed to fulfill three specific aims. First, fresh brain tissue will be obtained within 30-60 minutes after death through the Rapid Autopsy Program, a unique feature of this Center. Second, the Staff of the Kathleen Price Bryan Brain Bank will acquire specimens, establish pathological diagnoses, dissect and store brain tissue from demented and control patients, and release specimens to qualified investigators. Third, the Brain Bank will coordinate a routing service for histological neuropathological and neurochemical data. As part of this data management function, the Brain Bank will coordinate its data- gathering activities with those of the Research Clinical Core.