Cooperative motor control of the pyloric junction by myogenic and neuronal mechanisms

通过肌源性和神经元机制对幽门连接处的协作运动控制

• 批准号: nhmrc : 160005
• 负责人: Prof Marcello Costa
• 金额: $ 18.11万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cooperative-motor-control-neuronal-mechanisms/76086
• 关键词: Cooperative; motor; control; pyloric; junction

The coordinated muscle movement in the junction between the stomach and small intestine is an essential mechanism for controlling the speed of gastric content moving into the intestine for further digestion. The muscle movement determines the gastric emptying at an optimal rate and prevents intestinal contents reflux to the stomach. Failure of this coordination is likely to be involved in a variety of clinical conditions including accelerated or delayed gastric emptying. Up to date, little information is available about the interaction between nerve, muscle and pacemaker cells during this coordinated movement. In this project, we will investigate how the nerve, muscle and pacemaker cells work together to control this coordinated movement. We will study this mechanism at both cellular and organ levels and try to establish the patterns of muscle movement and their coordination between the stomach and the small intestine. The interaction between the nerve and pacemaker cells will be characterised in these studies. Our work will provide structural evidence for this activity. It includes identification of the nerve pathways connecting between the small intestine and stomach and determination of whether the pacemaker cell network is an uniform continuous or a discontinuous or a transitional structure across the junction. These studies will reveal the correlation between pacemaker cell mediated activity and the density of these cells in each junctional region. We will also determine whether the difference in propagation activity across the junction is due to differences in the number of cells for signal conduction or electrical connections between the cells. This study will advance our knowledge for understanding how the nerve, muscle and pacemaker cells work in concert in this junction, which is an important step for further clinical investigation of related disease.

胃和小肠连接处的协调肌肉运动是控制胃内容物进入肠道进一步消化的速度的重要机制。肌肉运动决定胃排空的最佳速度，并防止肠内容物回流到胃。这种协调的失败可能与多种临床状况有关，包括胃排空加速或延迟。迄今为止，关于神经、肌肉和起搏细胞在这种协调运动过程中相互作用的信息很少。在这个项目中，我们将研究神经、肌肉和起搏细胞如何协同工作来控制这种协调运动。我们将在细胞和器官水平上研究这种机制，并尝试建立肌肉运动的模式及其在胃和小肠之间的协调。这些研究将表征神经和起搏细胞之间的相互作用。我们的工作将为这项活动提供结构证据。它包括识别连接小肠和胃之间的神经通路，并确定起搏细胞网络是否是跨连接的均匀连续或不连续或过渡结构。这些研究将揭示起搏细胞介导的活动与每个连接区域中这些细胞的密度之间的相关性。我们还将确定跨连接处的传播活性的差异是否是由于用于信号传导或细胞之间的电连接的细胞数量的差异造成的。这项研究将增进我们对神经、肌肉和起搏细胞如何在该连接处协同工作的认识，这是进一步临床研究相关疾病的重要一步。