PCR 诊断卡氏肺囊虫肺炎的有效性评估-猫眼课题宝

PCR 诊断卡氏肺囊虫肺炎的有效性评估

批准号：

3752266

负责人：

C P CARTWRIGHT

金额：

$0.0万

依托单位：

CLINICAL CENTER

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3752266

关键词：

Pneumocystis carinii Pneumocystis pneumonia bacterial DNA communicable disease diagnosis diagnosis design /evaluation diagnostic tests enzyme linked immunosorbent assay polymerase chain reaction rapid diagnosis sputum

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英文摘要

We developed a rapid, yet efficient procedure for extracting DNA from respiratory specimens, and a user friendly ELISA format PCR product detection assay. By combining these two technologies we were able to perform, in a diagnostic laboratory, a prospective evaluation of PCR as a method for diagnosing Pneumocystis carinii pneumonia (PCP). The results of this study indicate that the use of PCR could improve the efficiency of diagnosis of PCP, especially from non-invasive specimens (induced sputa). The improvement in diagnosis effected by PCR was particularly marked in patients that, a priori, might be expected to produce sputum specimens containing a low number of organisms (for example HIV patients receiving chemoprophylaxis, immunosuppressed non HIV patients).

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