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ROLE OF MHC CLASS I IN THE GENERATION OF AUTOIMMUNE DISEASES

ROLE OF MHC CLASS I IN THE GENERATION OF AUTOIMMUNE DISEASES
I 类 MHC 在自身免疫性疾病产生中的作用
批准号：
3752139
负责人：
D SINGER
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3752139
关键词：
MHC class I antigen artificial immunosuppression autoimmune disorder autoimmunity disease /disorder model genetic regulation genetic transcription histocompatibility gene hormone regulation /control mechanism immunopharmacology laboratory mouse systemic lupus erythematosus thyroid hormones thyrotropin

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英文摘要
MHC class I genes are subject to both homeostatic, tissue-specific regulation and dynamic regulation. Among the mechanisms of dynamic regulation are those mediated by hormones that either increase or decrease transcription of the genes. The observation that TSH leads to decreased class I transcription, whereas thyroid hormone leads to increased transcription, led to the hypothesis that failure to appropriately regulate MHC class I molecules may play a pivotal role in the generation of autoimmune disease. Consistent with this hypothesis, it was demonstrated that in an experimental model of autoimmunity, animals that fail to express class I molecules are resistant to disease.
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