ROLE OF MHC CLASS I IN THE GENERATION OF AUTOIMMUNE DISEASES

I 类 MHC 在自身免疫性疾病产生中的作用

• 批准号: 3752139
• 负责人: D SINGER
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752139
• 关键词: MHC class I antigen; artificial immunosuppression; autoimmune disorder; autoimmunity; disease /disorder model; genetic regulation; genetic transcription; histocompatibility gene; hormone regulation /control mechanism; immunopharmacology; laboratory mouse; systemic lupus erythematosus; thyroid hormones; thyrotropin

MHC class I genes are subject to both homeostatic, tissue-specific regulation and dynamic regulation. Among the mechanisms of dynamic regulation are those mediated by hormones that either increase or decrease transcription of the genes. The observation that TSH leads to decreased class I transcription, whereas thyroid hormone leads to increased transcription, led to the hypothesis that failure to appropriately regulate MHC class I molecules may play a pivotal role in the generation of autoimmune disease. Consistent with this hypothesis, it was demonstrated that in an experimental model of autoimmunity, animals that fail to express class I molecules are resistant to disease.

MHC I类基因受体内平衡，组织特异性 监管和动态监管。在动态的机制中， 调节是由激素介导的， 基因的转录。 TSH导致降低的观察结果 I类转录，而甲状腺激素导致增加 转录，导致的假设，未能适当 调节MHC I类分子可能在生成中起关键作用， 自身免疫性疾病与这一假设相一致， 证明了在自身免疫的实验模型中， 不能表达I类分子的人对疾病有抵抗力。