课题基金 / 基金详情

ROLE OF MHC CLASS I IN THE GENERATION OF AUTOIMMUNE DISEASES

ROLE OF MHC CLASS I IN THE GENERATION OF AUTOIMMUNE DISEASES
I 类 MHC 在自身免疫性疾病产生中的作用
批准号：
3774432
负责人：
D SINGER
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3774432
关键词：
MHC class I antigen autoimmune disorder autoimmunity genetic regulation genetic transcription histocompatibility gene hormone regulation /control mechanism thyrotropin

项目摘要

项目成果

D SINGER的其他基金

相似基金

相关文献

中文摘要
翻译
MHC I类基因既受动态平衡的影响，又受组织特异性的影响 监管和动态监管。在动力机制中 调节是由荷尔蒙调节的调节，激素或增加或减少 基因的转录。促甲状腺激素(TSH)降低的观察 I类转录，而甲状腺激素导致增加 转录，导致假设未能适当地 调节MHC-I类分子可能在MHC-I的产生中起着关键作用 自身免疫性疾病。与这一假设一致的是， 证明在自身免疫的实验模型中，动物 未能表达I类分子对疾病的抗药性。
英文摘要
MHC class I genes are subject to both homeostatic, tissue-specific regulation and dynamic regulation. Among the mechanisms of dynamic regulation are those mediated by hormones that either increase or decrease transcription of the genes. The observation that TSH leads to decreased class I transcription, whereas thyroid hormone leads to increased transcription, led to the hypothesis that failure to appropriately regulate MHC class I molecules may play a pivotal role in the generation of autoimmune disease. Consistent with this hypothesis, it was demonstrated that in an experimental model of autoimmunity, animals that fail to express class I molecules are resistant to disease.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
HIV-MEDIATED REPRESSION OF MHC CLASS I GENE EXPRESSION
HIV-MEDIATED REPRESSION OF MHC CLASS I GENE EXPRESSION
HIV-MEDIATED REPRESSION OF MHC CLASS I GENE EXPRESSION
ISOLATION AND CHARACTERIZATION OF A NOVEL H-2 CLASS I GENE
海外基金