A CONTROLLED PROSPECTIVE STUDY OF TRANSFUSION-ASSOCIATED HEPATITIS

本研究调查输血后肝炎(PTH)的发病率。 在前瞻性跟踪的心内直视手术患者中 采取措施阻止有传染性的捐赠者。这些措施包括 献血员丙氨酸氨基转移酶(ALT)抗体序贯检测 对人类免疫缺陷病毒(抗HIV-1)、乙肝抗体 核心抗原(抗HBc)和丙型肝炎病毒抗体(抗丙型肝炎病毒) 以及对捐赠者的密集询问，以记录高危行为。 在1985至1990年间，肝炎发病率从10%下降到大约 3%。继第一代抗-丙型肝炎病毒检测方法问世后 发病率降至1.5%以下。我们现在正在跟踪甲状旁腺功能亢进的发生率 第二代抗-丙型肝炎病毒检测方法的使用和比率正在接近 300个收件人中为零。超过95%的PTH被归类为非 甲型、非乙型肝炎，其中约90%与丙型肝炎有关。 由于心脏直视手术计划的关闭，这些研究是 在乔治敦大学医院(GUH)和费尔法克斯进行 医院。

This study investigates the incidence of post-transfusion hepatitis (PTH) in prospectively followed open-heart surgery patients following a variety of measures to interdict infectious donors. These measures have included sequential testing of donors for alanine aminotransferase (ALT), antibody to the Human Immunodeficiency Virus (anti-HIV-1), antibody to hepatitis B core antigen (anti-HBC) and antibody to the hepatitis C virus (anti-HCV) as well as intensive donor questioning in record to high-risk behavior. Between 1985 and 1990, hepatitis incidence fell from 10% to approximately 3%. Following the introduction of First Generation anti-HCV testing incidence fell to under 1.5%. We are now following PTH incidence after the use of Second Generation anti-HCV assays and rates are approaching zero among 300 recipients. Greater than 95% of PTH is classified as non- A, non-B hepatitis and approximately 90% of this is HCV related. Because of closure of the !D open heart surgery program, these studies are being conducted at Georgetown University Hospital (GUH) and Fairfax Hospital.