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POST-TRANSFUSION HEPATITIS (PTH) IN OPEN HEART SURGERY PATIENTS

POST-TRANSFUSION HEPATITIS (PTH) IN OPEN HEART SURGERY PATIENTS
心脏直视手术患者的输血后肝炎 (PTH)
批准号：
3939415
负责人：
H J ALTER
金额：
$0.0万
依托单位：
CLINICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3939415
关键词：
Betaherpesvirinae Epstein Barr virus alanine transaminase antibody formation blood donor blood transfusion chronic disease /disorder communicable disease control epidemiology heart surgery hepatitis B antigens hepatitis C virus human subject longitudinal human study nosocomial infection control postoperative complications radioimmunoassay serology /serodiagnosis virus classification

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中文摘要
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英文摘要
To determine the incidence of hepatitis in prospectively followed open heart surgery patients receiving blood that has been pre- screened for donor transaminase (ALT) level and since 1986, for anti-core (anti-HBc) antibody. Blood units with elevated ALT or anti-HBc will be discarded. Hepatitis incidence will be compared with that of identically followed patients in previous studies in which no attempts was made to exclude blood with these surrogate markers. In previous studies blood units with elevated ALT or anti-HBc were more frequently associated with recipient hepatitis than units with normal values. Cases of hepatitis will be serologically assessed for virus etiology and patients will be carefully followed for the development of chronic hepatitis.
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