TRANSMISSION OF HTLV-III (AIDS) INFECTION TO THE CHIMPANZEE

将给三只黑猩猩接种血浆或富淋巴细胞血浆 来自艾滋病谱不同阶段的多名患者。大型 体积将被用来模拟人体输血体验。 将对动物进行监测，以寻找艾滋病的临床和免疫学证据 将对HTLV-III进行抗体血清转换筛查，假设 艾滋病的代理人。这项研究的目的是证明存在一个 人血浆中的艾滋病传播因子及动物模型的建立 用于疫苗和其他研究。 在这项研究的第二阶段，重点将放在建立一个 艾滋病可复制疾病模型。为了诱导临床表现， 将采用模拟人类体验的条件，即 重复接种病毒，与其他病毒合并感染和 免疫刺激和/或抑制。免疫刺激系统将会在 外源蛋白(人凝血因子VII浓缩物)的形式和同种异体 细胞。

Three chimpanzees will be inoculated with plasma or lymphocyte rich plasma from multiple patients in various stages of the AIDS spectrum. Large volumes will be utilized to simulate the human transfusion experience. Animals will be monitored for clinical and immunologic evidence of AIDS and will be screened for antibody seroconversion to HTLV-III, the postulated agent of AIDS. The study is aimed at proving the existence of a transmissible AIDS agent in human plasma and establishing an animal model for vaccine and other studies. In a second phase of this study, emphasis will be placed on establishing a reproducible disease model for AIDS. To induce clinical manifestations, conditions simulating the human experience will be employed, namely repeated inoculation of virus, coinfection with other viruses and immunologic stimulation and/or suppression. Immunostimulation will be in the form of foreign protein (human factor VII concentrates) and allogenic cells.