INSTRUMENTAL ANALYSIS

仪器分析

• 批准号: 3752802
• 负责人: G H WEISS
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752802
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; clinical biomedical equipment; computer program /software; computer simulation; computer system design /evaluation; nuclear magnetic resonance spectroscopy; positron emission tomography; single photon emission computed tomography

This project has several components related to different biomedical instrumentation modalities. One type of study is to find optimal designs for measuring in vivo first-order rate constants by means of NMR magnetization transfer experiments. It is important to make these measurements as quickly as possible to minimize artifacts due to physiological changes that might occur during the course of the experiment. In the course of a project currently being completed, an easily-implemented optimal experiment was designed, using the assumption that the experimenter knows an a priori range for the rate constant, but also that the associated spin-lattice relaxation time (T1) is known. This somewhat artificial assumption is dropped in the current approach to this problem. A project related to many aspects of medical imaging has required the development of a simulation package to examine problems raised by positron-emission tomography (PET) and single-photon emission tomography (SPECT). For this purpose, a currently available program (SIMSET, developed at the University of Washington) has been modified to more accurately model the design of equipment in general hospital use. Several projects using this program will be undertaken in the coming year.

该项目有几个组成部分，涉及不同的生物医学 仪器形式。一种研究是寻找最优设计 用于通过NMR测量体内一级速率常数 磁化传递实验重要的是要使这些 尽可能快地进行测量，以最大限度地减少由于 生理变化，可能发生的过程中， 实验在目前正在完成的一个项目中， 设计了一个易于实施的优化实验，利用假设 实验者知道速率常数的先验范围，但是 还知道相关的自旋-晶格弛豫时间（T1）。这 在目前的方法中， 问题. 一个与医学成像的许多方面相关的项目需要 开发一套模拟软件，以研究 正电子发射断层扫描（PET）和单光子发射断层扫描 （SPECT）。为此，目前可用的程序（SIMSET， 在华盛顿大学开发）已被修改为更多 准确地设计出适合一般医院使用的模型设备。几 利用这一方案的项目将在明年实施。