INSTRUMENTAL ANALYSIS

仪器分析

• 批准号: 3838513
• 负责人: G H WEISS
• 金额: --
• 依托单位: CENTER FOR INFORMATION TECHNOLOGY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3838513
• 关键词: bioengineering /biomedical engineering; mathematical model; method development; nuclear magnetic resonance spectroscopy

This project focusses on the basic accuracy of NMR measurements and the design of experiments for such measurements to minimize errors due to instrumental noise. We have made experimental measurements on a number of spectrometers to verify the absence of significant correlations in the noise which would necessitate changes in the analysis. A natural extension of our earlier work on optimal design of NMR experiments is to adaptive designs, to reduce instrumental running times and improve the precision of estimates of spin lattice relaxation times. This parameter finds wide application in chemistry and medical imaging. We have developed a set of partially adaptive optimal designs which allow for two stages, in estimating T1, the design of the second being based on results from the first. This is relatively simple to implement and generally reduces the running time and increases precision. An additional extension of the theory is that of designing optimal experiments for the measurement of rate constants for in-vivo experiments. This work is still in progress.

该项目的重点是NMR测量的基本准确性， 设计这种测量的实验，以尽量减少由于 仪器噪音。 我们已经对一个 光谱仪的数量，以验证不存在显着的 噪声中的相关性，这将需要改变 分析. 一个自然的延伸，我们的早期工作的最佳设计， 核磁共振实验是适应性设计，以减少仪器运行 提高了自旋晶格弛豫估计的精度 次 该参数在化学和医学中有着广泛的应用 显像 我们提出了一组部分自适应最优设计 这允许两个阶段，在估计T1时，第二个阶段的设计 基于第一次的结果。 这相对简单， 实施，并普遍减少运行时间，并增加 精度 该理论的另一个扩展是设计 最佳实验，用于测量体内的速率常数 实验 这项工作仍在进行中。