GENOBASE--AN OBJECT ORIENTED GENOMIC DATABASE ACCESSIBLE THROUGH THE WWW/MOSAIC

正在进行工作，以开发和提供一个综合框架， DNA/蛋白质序列比较研究的计算支持 跨多个基因组/物种的分析和相关领域。其中的逻辑 在整个项目中使用编程语言Prolog，允许 快速有效地合并不同类型的数据，以及 允许来自集成数据的复杂查询。工具集开发 与R.Overbeek博士和R.Hagstrom博士密切合作 阿贡国家实验室。 目前的工作重点是将大量数据从 多个源，从而产生唯一的资源，将来自 GenBank、EMBL、ProSite、SwissProt和 其他数据包括奥弗贝克博士的俄罗斯合作者提供的代谢数据。 这将与DNA和蛋白质序列、基序、 多个基因组的代谢途径和其他数据。这项工作 结合了基因组组织和遗传调控的分析 代谢途径。该数据库和相关工具将允许回答 对于使用标准很难或不可能满足的查询 目前可用的生物数据库。 该数据库也是万维网的底层数据存储库 (WWW)由R.Taylor和A.Ginsburg实现的超文本浏览器， DCRT/BIMAS。预计这项WWW服务将提供一个独特的 通过互联网向生物医学研究社区提供资源，雇用 简单且广泛可用的最终用户客户端工具，例如用于 进入。这将补充NCBI和EMBL的现有WWW服务器 欧洲，提供迄今为止无法提供的独特服务。

Work is ongoing to develop and provide an integrated framework for computational support of research in comparative DNA/protein sequence analysis and related areas across multiple genomes/species. The logic programming language PROLOG is used throughout this project, permitting data of disparate types to be combined rapidly and effectively, and permitting complex queries from the integrated data. Toolset development was performed in close collaboration with Drs. R. Overbeek and R. Hagstrom of Argonne National Laboratory. Current work focuses on the addition of large volumes of data from multiple sources, resulting in a unique resource, combining data from a number of current sources such as GenBank, EMBL, Prosite, SwissProt and others including metabolic data from Dr. Overbeek's Russian collaborators. This will form integrated database with DNA and protein sequence, motif, metabolic pathway and other data for multiple genomes. The work incorporates analysis of genomic organization and genetic regulation of metabolic pathways. This database and associated tools will permit answers to queries that are difficult or impossible to satisfy using the standard biological databases currently available. This database is also the underlying data repository for a World-Wide Web (WWW) hypertext browser implemented by R. Taylor and A. Ginsburg, DCRT/BIMAS. It is expected that this WWW service will provide a unique resource to the biomedical research community over the Internet, employing simple and widely available end-user client tools, such as NCSA Mosaic for access. This will supplement present WWW servers at NCBI and at EMBL in Europe, providing unique services unavailable to date.