GENOBASE--AN OBJECT ORIENTED GENOMIC DATABASE ACCESSIBLE THROUGH THE WWW/MOSAIC

正在进行工作，以开发和提供一个综合框架， DNA/蛋白质序列比较研究的计算支持 跨多个基因组/物种的分析和相关领域。其中的逻辑 在整个项目中使用编程语言Prolog，允许 快速有效地合并不同类型的数据，以及 允许来自集成数据的复杂查询。工具集开发 与Ross Overbeek博士和R. 阿贡国家实验室的哈格斯特罗姆。 目前的工作重点是将大量数据从 多个源，从而产生唯一的资源，将来自 GenBank、EMBL、ProSite、SwissProt和 其他的，包括奥弗贝克博士的俄罗斯人的代谢数据 合作者。这将与DNA和 蛋白质序列数据、肽基序DTA、代谢途径数据以及 其他跨多个基因组的数据。这项工作结合了对 代谢途径的基因组组织和遗传调控。这 数据库和相关工具将允许回答以下查询 使用标准的生物学很难或不可能满足 可用的数据库。 该数据库也是万维网的底层数据存储库 (WWW)由R.Taylor和A.Ginsburg实现的超文本浏览器 DCRT/BIMAS。预计这项WWW服务将提供一个独特的 通过互联网向生物医学社区提供资源，使用简单的 以及广泛可用的终端用户客户端工具，如Netscape，用于访问。 这将补充NCBI和EMBL在欧洲的现有WWW服务器， 提供独特的服务，这是迄今为止无法提供的。

Work is ongoing to develop and provide an integrated framework for computational support of research in comparative DNA/protein sequence analysis and related areas across multiple genomes/species. The logic programming language PROLOG is used throughout this project, permitting data of disparate types to be combined rapidly and effectively, and permitting complex queries from the integrated data. Toolset development was performed in close collaboration with Drs. Ross Overbeek and R. Hagstrom of Argonne National Laboratory. Current work focuses on the addition of large volumes of data from multiple sources, resulting in a unique resource, combining data from a number of current sources such as GenBank, EMBL, Prosite, SwissProt, and others, including metabolic data from Dr. Overbeek's Russian collaborators. This will form an integrated database with DNA and protein sequence data, peptide motif dta, metabolic pathway data, and other data across multiple genomes. The work incorporates analysis of genomic organization and genetic regulation of metabolic pathways. This database and associated tools will permit answers to queries that are difficult or impossible to satisfy using the standard biological databases that are available. This database is also the underlying data repository for a World Wide Web (WWW) hypertext browswer implemented by R. Taylor and A. Ginsburg of DCRT/BIMAS. It is expected that this WWW service will provide a unique resource to the biomedical community over the Internet, employing simple and widely available end-user client tools, such as Netscape, for access. This will supplement present WWW servers at NCBI and at EMBL in Europe, providing unique services unavailable to date.