LOGIC PROGRAMMING-BASED DATABASE AND QUERY SYSTEM FOR GENOMIC DATA

计算分析提供给乔治迈克尔斯博士， 比较DNA序列分析的研究和构建 公共领域的工具，供生物学家使用， 多重基因组 继续开展工作，分析全球 组织选定的基因组和定义当地的监管 代谢途径的遗传调节的语法。 一个共同 所有这些工作的一个特点是逻辑编程语言PROTECH。 使用 PROTEGO的功能使我们能够快速地将不同类型的联合收割机数据组合在一起 开发对集成数据进行复杂查询的能力。 与Ross博士密切合作开发工具集 奥弗贝克和阿贡国家实验室的雷·哈格斯特罗姆博士。 援助 在分析这项工作产生的数据时也给出了。 几 出版物产生了。 生物数据库的合作 阿贡国家实验室继续建设，目前 重点是增加和整合大量的 代谢数据转换为DNA和蛋白质序列数据。

Computational analysis was provided to Dr. George Michaels for his research in comparative DNA sequence analysis and for the construction of public domain tools for biologists to use in such analysis across multiple genomes. Work continued in the analysis of the global organization of selected genomes and the definition of local regulatory grammars for the genetic regulation of metabolic pathways. A common feature of all such work was the logic programming language PROLOG. Use of PROLOG allowed us to combine data of disparate types and rapidly develop the ability to pose complex queries of the integrated data. Toolset development was performed in close collaboration with Dr. Ross Overbeek and Dr. Ray Hagstrom of Argonne National Laboratory. Aid was also given in the analysis of the data generated by this work. Several publications have resulted. The collaboration on biological database construction continues with Argonne National Laboratory, with the current emphasis being on the addition and integration of large volumes of metabolic data to DNA and protein sequence data.