ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
批准号:
3754183
负责人:
J W DALY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
易位后的钙、钠、钾、镁离子
英文摘要
Calcium, sodium, potassium, and magnesium ions after translocation
through ion channels or by transport proteins can cause activation of
release processes, contractile proteins, adenylate and guanylate cyclase,
phosphodiesterases, protein kinases, phospholipases, ATPases and other
enzymes. Receptors of various types and various toxins serve to modulate
ion channels and generation of second messengers including cyclic
nucleotides, diacylglycerides, arachidonic acid and phosphatidic acid.
Modulatory interactions or "cross-talk" occurs both between the second
messenger systems and with the ion transport systems. Maitotoxin, a
marine polyether increases phospholipid breakdown, leading to inositol
phosphate and diacyclglyceride production. The primary site of action
of maitotoxin appears to be a calcium channel. The maitotoxin-responses
are effectively blocked by imidazoles that are also effective in blocking
the so-called calcium-release-activated calcium (CRAC) channels, which
are activated in plasma membranes of cells when IP3-sensitive
intracellular stores of calcium are depleted either through receptor-
activation of phospholipase C or through blockade of intracellular Ca++-
ATPases by thapsigargin. However, other calcium blockers that prevent
maitotoxin-responses do not block CRAC channels activated by ATP or fmLP
in HL-60 cells. These include fluspirilene, penfluridol, loperamide and
proadifen. The imidazoles (econazole, miconazole, SKF 96365,
clotrimazole, calmidazolim) not only block maitotoxin-responses and CRAC
channels, but also elicit per se an influx of calcium. Loperamide, while
having no effect on [Ca2+]; alone, appears to enhance CRAC channel-
elicited influx. ATP activates phosphoinositide breakdown in HL-60 cells
through a P2u-receptor. In PC12 cells, ATP activates phosphoinositide
breakdown through both P2u and P2y-receptors. In addition, ATP triggers
calcium influx in PC12 cells through another P2-receptor. Activation of
P2y- but not P2u-receptors leads to a sustained elevation of
intracellular calcium presumably via CRAC channels, an activation of
calcium-dependent potassium channels and release of norepinephrine.
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ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:5201962
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:6161943
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3776290
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS--RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3875849
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3940629
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:2572985
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3964464
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3875848
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3917733
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3875853
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3940631
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3964466
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:5201957
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项目类别:
-
资助金额:$0.0万
-
财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:5201959
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:4689665
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3839843
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3839849
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
-
依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3776288
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3754186
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:2572988
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
海外基金