CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
批准号:
3940631
负责人:
J W DALY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
adenosine adenylate cyclase arachidonate brain metabolism central nervous system chemical structure function cyclic AMP cyclic GMP diacylglycerols human tissue inositol phosphates neoplastic cell culture for noncancer research neural information processing neurochemistry neurotransmitters nucleoside analog phorbols phosphatidylinositols protein kinase C tissue /cell culture xanthine analog xanthines
中文摘要
生理功能在不同的细胞中是通过一种
多种第二信使,包括环状AMP和环状GMP。
钙、钠和镁等离子在
通过离子通道或运输蛋白转运,如
第二信使激活离子的释放,并激活
反式蛋白、蛋白激酶、磷脂酶、ATPase和
其他酶。磷脂的酶解也可以
生成第二信使,如花生四烯酸,其作用是
前列腺素的前体;二酰甘油酯,其作用是
蛋白激酶C的激活剂;以及肌醇磷酸盐,它们
作为体内钙离子的激动剂。不同的受体
类型用于调节第二信使的生成。这个
第二信使和受体的相互关系与
用于这种体系的选择性试剂的描述已经被
调查过了。佛波醇酯,它类似于甘油二酯
激活蛋白激酶C,抑制受体介导的
神经母细胞瘤-杂交细胞系中的环磷酸腺苷。各种各样的
激活电压依赖的受体激动剂和药物
钠或钙通道引起磷脂酶C的激活
以及突触神经体中肌醇磷脂的分解。
佛波酯可抑制这些反应。一个很小的亚群
对镉离子高度敏感和低灵敏度的钠离子通道
对河豚毒素的敏感性似乎与
磷酸肌醇代谢。腺苷刺激环磷酸腺苷
通过A2受体形成并抑制环磷酸腺苷
通过A1受体形成。一系列腺苷类似物
已经被取消了药理学特征
参与腺苷生理功能的受体。一个
各种非黄嘌呤杂环,包括一系列N6-
取代-9-甲基腺嘌呤的特征是
腺苷受体拮抗剂某些黄嘌呤类似物已被
显示出作为低血压拮抗剂的选择性作用
腺苷的作用,腺苷的心脏抑制作用
以及腺苷和尼古丁之间的协同作用。
英文摘要
Physiological functions are mediated in different cells by a
variety second messengers including cyclic AMP and cyclic GMP.
Ions such as calcium, sodium and magnesium can serve after
translocation through ion channels or by transport proteins as
second messengers to activate release of ions, and activation of
contratile proteins, protein kinases, phospholipases, ATPases and
other enzymes. Enzymatic hydrolysis of phospholipids can also
generate second messengers such as arachidonate, which serves as
a precursor of prostanoids; diacylglycerides, which serve as
activators of protein kinase C; and inositol phosphates, which
serve as mobilizers of internal calcium ions. Receptors of various
types serve to modulate generation of second messengers. The
interrelationships of second messengers and receptors and the
delineation of selective agents for such systems have been
investigated. Phorbol esters, which like the diacylglycerides
activate protein kinase C, inhibit receptor-mediated formation of
cyclic AMP in a neuroblastoma-hybrid cell line. A variety of
receptor agonists and agents that activate voltage-dependent
sodium or calcium channels cause activation of phospholipase C
and breakdown of phosphoinositides in synaptoneurosomes.
Phorbol esters inhibit these responses. A small subpopulation of
sodium channels with high sensitivity to cadmium ions and low
sensitivity to tetrodotoxin appear losely associated with
phosphoinositude metabolism. Adenosine stimulates cyclic AMP
formation through an A2 receptor and inhibits cyclic AMP
formation through an A1 receptor. A series of adenosine analogs
have been delinated for pharmacological characterization of
receptors involved in physiological functions of adenosine. A
variety of non-xanthine heterocycles, including a series of N6-
substituted-9-methyladenines have been characterized as
adenosine receptor antagonists certain xanthine analogs have been
shown to have selective effects as antagonists of the hypotensive
effects of adenosine, the cardiac depressant effects of adenosine
and the synergism between adenosine and nicotine.
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ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:5201962
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:6161943
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3776290
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS--RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3875849
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3940629
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:2572985
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3964464
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3875848
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3754183
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3917733
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3875853
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3964466
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:5201957
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:5201959
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:4689665
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3839843
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3839849
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3776288
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3754186
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:2572988
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
海外基金