PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
批准号:
3875848
负责人:
J W DALY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Anura alkaloids amidines analgesics animal poison batrachotoxins chemical binding chemical structure function drug metabolism heart pharmacology infrared spectrometry mass spectrometry muscle pharmacology neuropharmacology neurotoxins nicotinic receptors piperidine potassium channel skin sodium channel
中文摘要
天然产物提供了广泛的生物活性制剂,
英文摘要
Natural products have provided a wide range of biologically active agents,
many of which have unique profiles of pharmacological activity and
therapeutic potential. Over two hundred alkaloids have been identified In
extracts from amphibian skins. These include batracbotoxins, which are
potent activators of sodium channels, histrionicotoxins, Which are
noncompetitive blockers of nicotinic receptor channel complexes and of
potassium channels, and pumiliotoxins, which have myotonic and cardiotonic
activity (iii(- to inhibitory effects on closing of sodium channels. A
variety of further alkaloids have, been characterized from dendrobatid
frogs. These include new 2,5-disubstituted decahydroquinolizies
5,8-disubstited indolizidines, 6,9-disubstituted quinolizidines,
3,5-disubstituted pyrrolizidines, pumiliotoxins, homopumiliotoxins and
allopumilliotoxins. Many of these alkaloids have activity as noncompetitive
blockers at muscle-type and ganglionic-type nicotinic receptor-channels.
Structures for three tricyclic pyrrolizidinone oximes and O-mothyloximes
from a dendrobatid frog have been determined based on analysis by mass
spectrometry, infrared spectroscopy and nuclear magnetic resonance
spectrometry. A structure for the parent member (C(11)H(13)N(2)Cl(2) ) a
new class of analgetic alkaloids has been similarly derived by analysis of
an N-acetyl derivative. Characterization of alkaloids in nondendrobatid
amphibians indicates that the biosynthetic pathways to certain dendrobatid
alkaloids have evolved separately in one lineage (genus) of amphibians from
the families Bufonidae, Myobatracidae and Ranidae and in a lineage leading
to four genera in the family Dendrobatider. The lack of alkaloid production
in captive-raised dendrobatid frogs now appears due to lack of natural
environment and/or diet. A peptide (thirty amino acid residues) isolated
from mucous secretions of a hylid frog Phyllomedusa bicolor causes profound
behavioral depression land stimulates binding of adenosine agonists to
brain A(1)-adenosine receptors.
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ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:2572985
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:5201962
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3940629
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS--RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3875849
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3776290
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:6161943
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3964464
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3940631
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ION CHANNELS, RECEPTORS AND SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3754183
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3875853
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3917733
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
CYCLIC NUCLEOTIDES AND OTHER SECOND MESSENGERS IN THE NERVOUS SYSTEM
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批准号:3964466
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:5201957
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:2572988
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:2572984
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3754186
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3776288
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项目类别:
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资助金额:$0.0万
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:3839843
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
ADENOSINE RECEPTOR AGONISTS AND ANTAGONISTS
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批准号:3839849
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
PHARMACOLOGICALLY ACTIVE COMPOUNDS FROM AMPHIBIANS AND OTHER NATURAL SOURCES
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批准号:6161942
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:J W DALY
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依托单位:
国内基金
海外基金
Iboga alkaloids骨架导向的不对称串联反应构建吖庚环并[4,5-b]吲哚及其在全合成中的应用
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批准号:21801032
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项目类别:青年科学基金项目
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资助金额:26.0万元
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批准年份:2018
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负责人:陈惠渝
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依托单位: