PERINATAL EMPHASIS RESEARCH CENTER GRANT

围产期重点研究中心拨款

• 批准号: 2198077
• 负责人: REGINALD C TSANG
• 金额: $ 53.63万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-30 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2198077
• 关键词: perinatal; prenatal growth disorder

The long-term objective of the Center is to optimize fetal and neonatal growth and to decrease fetal and infant morbidity and mortality. These goals will be accomplished by defining and understanding the basic physiology of fetal and neonatal growth and growth retardation. The overall thesis examined is that specific growth factors are principal regulators of growth and development of the fetus and infant. Drs. Tsang, Clark, Handwerger, and Whitsett provide the administrative organizational framework for the PERC. The Molecular Core provides a central site for molecular norphologic studies and training in in situ hybridization and immunocytochemistry, directed by Dr. Jeff Whitsett. Drs. Korfhagen and Whitsett will identify a progenitor during branching morphogenesis and Type II cytodifferentiation in the fetal lung. Drs. Weaver and Drake will test the hypothesis that the temporal and spatial regulation of pulmonary glycogen metabolism, in the developing respiratory epithelium, is correlated with the pre-translational regulation of glycogen synthase (Project B) and phosphorylase kinase (Project A). Dr. Lieberman examines the thesis that injections of neonatal rats with epidermal growth factor alters ontogenic expression of fibroblast growth factors (FGFs). Drs. Hoath and Donnelly test the thesis that perturbations of perinatal growth; i.e. placental insufficiency or exposure to exogenous EGF, will alter molecular events of early homeothermic adaptation in brown adipose tissue and imprint aberrant patterns of metabolic function in adults. Drs. Chernausek and Smith examine the thesis that carrier proteins for insulin- like growth factors are physiologically-regulated modulators of IGF action during the perinatal period. Dr. Iwamoto tests the hypothesis that the placenta and fetal liver regulated plasma concentrations of IGF-I and thus coordinate fetal growth. Dr. Clark tests the thesis that chronic reduced uteroplacental blood flow leads to asymmetric growth retardation and reduced IGF-I by altering delivery and uptake of oxygen, glucose, and amino acids by the placenta and fetus while also testing the thesis that direct fetal supplementation with nutrients and maternal oxygen administration can prevent IUGR. Thus in this Center, molecular biologic, cellular, physiologic, and a clinical study complement each other in an integrated multidisciplinary study.

该中心的长期目标是优化胎儿和新生儿 这将有助于儿童的成长，并降低胎儿和婴儿的发病率和死亡率。这些 目标将通过定义和理解基本的 胎儿和新生儿生长和生长迟缓的生理学。这个 研究的总体论点是，特定的增长因素是主要的 胎儿和婴儿生长发育的调节器。尊敬的曾博士， 克拉克、汉德沃格和惠特塞特提供了管理组织 PERC的框架。分子核心提供了一个中心位置 原位杂交和分子生物学方面的研究和培训 由杰夫·惠特塞特博士指导的免疫细胞化学。科夫亨博士和 惠特塞特将在分枝形态发生和类型期间确定祖细胞 II胎肺的细胞分化。韦弗博士和德雷克博士将测试 肺组织的时空调节机制假说 在发育中的呼吸道上皮中，糖原代谢是 与糖原合成酶的翻译前调控相关 (项目B)和磷酸化酶激酶(项目A)。利伯曼博士检查 新生大鼠注射表皮生长因子的研究 改变成纤维细胞生长因子(FGFs)的个体表达。戴维斯博士。 霍斯和唐纳利检验了这一论点，即围产期生长的扰动； 即胎盘功能不全或暴露于外源性EGF，将改变 棕色脂肪组织早期恒温适应的分子事件 并印记了成年人代谢功能的异常模式。戴维斯博士。 切尔纳塞克和史密斯研究了胰岛素载体蛋白-- 类似的生长因子是IGF作用的生理调节因子 在围产期。岩本博士测试了这样一种假设 胎盘和胎肝调节血浆IGF-I浓度，从而 协调胎儿生长。克拉克博士测试了慢性减少的论点 子宫胎盘血流导致非对称性生长迟缓和 通过改变氧、葡萄糖和氨基酸的输送和摄取来降低IGF-I 胎盘和胎儿的酸性物质，同时也测试了这一命题 胎儿补充营养和母体吸氧可以 预防宫内发育迟缓。因此，在这个中心，分子生物学、细胞学、 生理学和临床研究在综合研究中相辅相成 多学科研究。