DIAGNOSIS AND TREATMENT OF HUMAN UVEITIS AND AIDS-RELATED OCULAR DISEASE

该项目的标题已从“诊断和诊断”改为 人类葡萄膜炎的治疗对人类的诊断和治疗 葡萄膜炎和与艾滋病有关的眼部疾病“，以反映扩大的范围 该项目将包括对艾滋病患者眼部疾病的研究。 此外，该项目还曾被列入 免疫学，但现在列在临床科。这样做的目的是 该项目是开发诊断和治疗人类疾病的改进方法 葡萄膜炎和艾滋病相关的眼部疾病。这个项目包括临床 评估新的诊断和治疗方法和免疫学的试验 以及对患者血液和组织标本的组织学研究 一些研究的重点是改进葡萄膜炎的诊断测试。 慢性泪囊炎患者泪腺和结膜活检的检查 结节病表现为淋巴细胞浸润和特异性T细胞 尽管没有肉芽肿形成，但受体谱系和这些结果 应有助于提高活检的诊断率 结节病。我们还表明，腰椎穿刺术可以漏掉恶性病变。 眼内淋巴瘤患者软脑膜的受累情况及临床意义 需要进行脑室引流。 临床科参与了多项旨在改善 葡萄膜炎和眼部恶性肿瘤的治疗。一个预期的，双倍的- 乙酰唑胺治疗葡萄膜炎相关性囊样病变的随机对照研究 黄斑水肿刚刚完成登记，今年将对数据进行分析 年。此外，我们完成了一项初步研究，考察了 一种化疗方案治疗中枢神经系统肿瘤的毒性反应 累及大脑或眼睛的神经系统淋巴瘤。一个完整的回应 在8名患者中有7名获得了；另一名患者有部分 回应。肝素表面修饰眼内注射的临床研究 葡萄膜炎患者的晶状体治疗正在进行中，一项关于葡萄膜炎的自然史研究 患有葡萄膜炎和视力良好的患者正在进行中。 最后，临床科参与眼部并发症的研究。 与艾滋病有关。我们正在回顾眼科 550例艾滋病患者眼科检查提高眼科诊断率 感染等并发症。此外，我们还参与了一项 地多福韦治疗耐药巨细胞病毒的开放研究 艾滋病患者的(CMV)视网膜炎。

The title of this project has been changed from "The Diagnosis and Treatment of Human Uveitis" to "The Diagnosis and Treatment of Human Uveitis and AIDS-Related Ocular Disease," to reflect the expanded scope of the project to include the study of ocular disease in patients with AIDS. In addition, this project was previously listed in the Laboratory of Immunology but is now listed in the Clinical Branch. The goal of this project is to develop improved methods for diagnosing and treating human uveitis and AIDS-related ocular disease. This project encompasses clinical trials evaluating new diagnostic and therapeutic approaches and immunologic and histologic studies on blood and tissue specimens obtained from patients A number of studies have focused on improving diagnostic tests for uveitis. Examination of lacrimal gland and conjunctival biopsies from patients with sarcoidosis has demonstrated lymphocytic infiltration and specific T-cell receptor repertoires despite a lack of granuloma formation, and these resul should help improve the diagnostic yield of biopsies for the diagnosis of sarcoidosis. We have also shown that lumbar puncture can miss malignant involvement of the leptomeninges in patients with intraocular lymphoma and that ventricular taps are needed. The Clinical Branch is involved in a number of studies designed to improve the treatment of uveitis and ocular malignancy. A prospective, double- masked, randomized study of acetazolamide for uveitis-associated cystoid macular edema has just completed enrollment, and data will be analyzed this year. In addition, we completed a pilot study examining the efficacy and toxicity of a chemotherapy regimen for therapy of patients with central nervous system lymphoma involving the brain or eye. A complete response was obtained in seven of eight patients; the other patient had a partial response. A clinical trial evaluating a heparin surface-modified intraocul lens in patients with uveitis is under way, and a natural history study of patients with uveitis and good vision is in progress. Finally, the Clinical Branch is involved in studies with ocular complicatio related to AIDS. We are retrospectively reviewing the ophthalmologic examinations of 550 AIDS patients to improve diagnosis of ocular complications such as infection. In addition, we are participating in an open-label study of didofovir for the treatment of resistant cytomegaloviru (CMV) retinitis in patients with AIDS.