CELL ADHESION MOLECULES IN OCULAR INFLAMMATION

细胞黏附分子是一种表面蛋白，它介导了 细胞到细胞外基质和到其他细胞。细胞的表达 黏附分子，这对白细胞迁移到 炎症部位，并部分由分泌的 细胞因子。我们正在研究细胞黏附分子在卵巢癌中的表达。 眼，在眼部炎症的动物模型和人眼 葡萄膜炎。 在过去的一年里，我们展示了内皮细胞的表达 Lewis患者角膜内皮细胞上白细胞黏附分子-1(ELAM-1)的表达 内毒素性葡萄膜炎大鼠。ELAM-1的表达位于 中性粒细胞的结合和角膜沉淀物的形成。在人类中 患有后葡萄膜炎的眼睛，我们已经证明了淋巴细胞功能- 相关抗原1(LFA-1)表达在浸润性T淋巴细胞上。 视网膜和脉络膜。细胞间黏附分子1(ICAM-1)、 视网膜色素上皮上有LFA-1的受体。 对血管内皮细胞和视网膜神经胶质细胞的影响 发炎。肿瘤坏死因子水平升高，这是 在患葡萄膜炎的眼睛中表现出来，可能在诱导 这些黏附分子。我们还检测了粘附性的表达 眼内淋巴瘤患者眼组织中LFA-1和LFA-1的表达 艾滋病患者眼内淋巴瘤细胞表面ICAM-1的表达。在一个 无艾滋病患者继发性眼内淋巴瘤：ICAM-1而不是LFA-1 在肿瘤细胞上表达。黏附分子在淋巴瘤组织中的表达 细胞可能对眼部肿瘤的定位很重要。

Cell adhesion molecules are surface proteins that mediate the binding of cells to extracellular matrix and to other cells. The expression of cell adhesion molecules, which is important for the migration of leukocytes to sites of inflammation, and is partly regulated by the secretion of cytokines. We are studying the expression of cell adhesion molecules in the eye, in both animal models of ocular inflammation and human eyes with uveitis. Over the past year, we have demonstrated the expression of endothelial leukocyte adhesion molecule 1 (ELAM-1) on the corneal endothelium in Lewis rats with endotoxin-induced uveitis. Expression of ELAM-1 precedes the binding of neutrophils and the formation of keratic precipitates. In human eyes with posterior uveitis, we have shown that lymphocyte function- associated antigen 1 (LFA-1) is expressed on lymphocytes infiltrating the retina and choroid. Intercellular adhesion molecule 1 (ICAM-1), the counter receptor for LFA-1, was demonstrated on retinal pigment epithelium, on vascular endothelium, and on glial cells of the retina in areas of inflammation. Increased levels of tumor necrosis factor, which were demonstrated in eyes with uveitis, may play a role in the induction of these adhesion molecules. We have also examined the expression of adhesion molecules in eyes with intraocular lymphoma and demonstrated LFA-1 and ICAM-1 on cells from an intraocular lymphoma in a patient with AIDS. In a second intraocular lymphoma in a patient without AIDS, ICAM-1 but not LFA-1 was expressed on tumor cells. Expression of adhesion molecules on lymphoma cells may be important for the localization of the tumor in the eye.