Development of an innovative recombinant protein vaccine against Aeromonas veronii in European seabass using "omics" technologies (AeroVeroVacc)

使用“组学”技术开发针对欧洲鲈鱼维氏气单胞菌的创新重组蛋白疫苗 (AeroVeroVacc)

基本信息

  • 批准号:
    EP/Y026454/1
  • 负责人:
  • 金额:
    $ 29.8万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Fellowship
  • 财政年份:
    2024
  • 资助国家:
    英国
  • 起止时间:
    2024 至 无数据
  • 项目状态:
    未结题

项目摘要

Disease within aquaculture systems has led to significant economic and production losses and is one of the main barriers to expanding sustainable aquaculture. Vaccination is widely accepted as an effective strategy to combat pathogenic diseases in aquaculture and a valuable alternative to antibiotics. An emerging bacterial infection caused by Aeromonas veronii has been the cause of significant mortalities in seabass farms in the Aegean Sea. Screening for novel virulence factors in vivo may be one approach for identifying potential vaccine candidates for vaccine development against Aeromonas veronii. A novel immuno-screeningtechnique, in vivo induced antigen technology (IVIAT), a method that relies on antibodies adsorbed against in vitro cultures of the pathogen, is used to identify immunogenic proteins on bacteria exclusively expressed in vivo during infection. This study will utilise cutting-edge technologies to identify genes specifically expressed or upregulated in vivo within the host. In vivo induced (IVI) proteins common to the three clades of A. veronii affecting European seabass will be selected to design a universal recombinant protein vaccine for A. veronii infections affecting European seabass in the Mediterranean. The project's multidisciplinary nature is strong, involving a combination of microbiology, fish immunology, molecular biology, fish vaccinology, fish health, and aquaculture.This interdisciplinarity approach is necessary to fulfil the overarching aim of delivering a universal recombinant protein vaccine for A. veronii affecting European seabass. Results emerging from the project will help find the chief proteins or genes that affect the virulence of the bacteria and their functions and relationships, as well as ultimately identify new virulence factors, especially for those pathogens that are antigenically diverse. This project is in line with the EU strategy for the sustainable development of aquaculture.
水产养殖系统内的疾病已导致重大经济和生产损失,是扩大可持续水产养殖的主要障碍之一。疫苗接种被广泛认为是防治水产养殖中病原性疾病的有效策略,也是抗生素的有价值的替代品。一种由韦罗尼气单胞菌引起的新出现的细菌感染已经成为爱琴海黑鱼养殖场重大死亡的原因。在体内筛选新的毒力因子可能是确定韦罗尼气单胞菌疫苗开发的潜在候选疫苗的一种方法。一种新的免疫筛选技术,体内诱导抗原技术(IVIAT),一种依赖于吸附在病原体体外培养上的抗体的方法,用于在感染期间识别细菌上仅在体内表达的免疫原蛋白。这项研究将利用尖端技术来识别宿主体内特定表达或上调的基因。在体内诱导(IVI)蛋白的三个分支共同影响欧洲黑鲈将被选择,以设计一种通用的重组蛋白疫苗感染影响地中海的欧洲黑鲨。该项目的多学科性质很强,涉及微生物学、鱼类免疫学、分子生物学、鱼类疫苗学、鱼类健康和水产养殖。这一跨学科方法对于实现为影响欧洲鲈鱼的韦罗尼弧菌提供通用重组蛋白疫苗的总体目标是必要的。该项目的结果将有助于找到影响细菌毒力及其功能和关系的主要蛋白质或基因,并最终确定新的毒力因素,特别是对那些抗原性多样化的病原体。该项目符合欧盟水产养殖业可持续发展战略。

项目成果

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Kimberly Thompson其他文献

Are all benefits equal? An exploratory analysis of coastal perspectives of seafood farming expansion in the United States
所有利益都是平等的吗?
  • DOI:
    10.1111/jwas.12956
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.8
  • 作者:
    Brianna K. Shaughnessy;Amalia Almada;Kimberly Thompson;Michelle Marvier;Peter Kareiva
  • 通讯作者:
    Peter Kareiva
Comparative evaluation of Polymerase Chain Reaction-Restriction Enzyme Analysis (PRA) and sequencing of heat shock protein 65 (hsp65) gene for identification of aquatic mycobacteria.
聚合酶链反应-限制性酶分析 (PRA) 和热休克蛋白 65 (hsp65) 基因测序对水生分枝杆菌鉴定的比较评估。
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    F. Pourahmad;Kimberly Thompson;Alexandra Adams;R. Richards
  • 通讯作者:
    R. Richards
Characterisation of the outer membrane proteome of Francisella noatunensis subsp. orientalis
诺阿图弗朗西斯菌亚种外膜蛋白质组的表征。
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Khalid Shahin;Kimberly Thompson;Neil F. Inglis;K. McLean;J. G. Ramírez;S. Monaghan;R. Hoare;Michael Fontaine;M. Metselaar;Alexandra Adams
  • 通讯作者:
    Alexandra Adams
Ultrastructural analysis of sequential cyprinid herpesvirus 3 morphogenesis in vitro.
连续鲤鱼疱疹病毒 3 型体外形态发生的超微结构分析。
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    S. Monaghan;Sven Bergmann;Kimberly Thompson;Linton Brown;T. Herath;Jorge Del;Alexandra Adams
  • 通讯作者:
    Alexandra Adams
Strategies and resources used by public health units to encourage COVID-19 vaccination among priority groups: a behavioural science-informed review of three urban centres in Canada
  • DOI:
    10.1186/s12889-025-21342-1
  • 发表时间:
    2025-01-31
  • 期刊:
  • 影响因子:
    3.600
  • 作者:
    Tori Langmuir;Mackenzie Wilson;Nicola McCleary;Andrea M. Patey;Karim Mekki;Hanan Ghazal;Elizabeth Estey Noad;Judy Buchan;Vinita Dubey;Jana Galley;Emily Gibson;Guillaume Fontaine;Maureen Smith;Amjad Alghamyan;Kimberly Thompson;Jacob Crawshaw;Jeremy M. Grimshaw;Trevor Arnason;Jamie Brehaut;Susan Michie;Melissa Brouwers;Justin Presseau
  • 通讯作者:
    Justin Presseau

Kimberly Thompson的其他文献

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{{ truncateString('Kimberly Thompson', 18)}}的其他基金

Development of a mucosally-delivered and active salmon louse vaccine for Atlantic salmon aquaculture
开发用于大西洋鲑鱼水产养殖的粘膜递送活性鲑鱼虱疫苗
  • 批准号:
    BB/Y006534/1
  • 财政年份:
    2024
  • 资助金额:
    $ 29.8万
  • 项目类别:
    Research Grant

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牙买加果蝠肠上皮的抗病毒免疫和耐受机制
  • 批准号:
    10592671
  • 财政年份:
    2023
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    $ 29.8万
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An innovative and straightforward approach to construct and manipulate viral infectious clones
构建和操作病毒感染性克隆的创新且简单的方法
  • 批准号:
    10667766
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ISPRI-HCP 的验证和改进:工艺相关蛋白质杂质免疫原性风险评估的创新平台
  • 批准号:
    10603538
  • 财政年份:
    2023
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    $ 29.8万
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Development of a Neutrophil Degranulation Inhibitor to Treat ARDS
开发治疗 ARDS 的中性粒细胞脱颗粒抑制剂
  • 批准号:
    10697442
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A Shared Neuroscience Platform for National Dissemination and Training in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies
一个共享神经科学平台,用于脑器官发生、行为和脑疾病模型、病毒载体和成像技术的全国传播和培训
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开发表达重组硬化素的稳定细胞系
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    $ 29.8万
  • 项目类别:
A Shared Neuroscience Platform for National Dissemination and Training in Brain Organogenesis, Behavioral and Brain Disease Models, Viral Vectors, and Imaging Technologies
一个共享神经科学平台,用于脑器官发生、行为和脑疾病模型、病毒载体和成像技术的全国传播和培训
  • 批准号:
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磁泳与光动力联合治疗TNBC
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Combined magnetophoresis and photodynamic therapy for the treatment of TNBC
磁泳与光动力联合治疗TNBC
  • 批准号:
    10586052
  • 财政年份:
    2021
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磁泳与光动力联合治疗TNBC
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