HYPERINSULIMEMIA AND ENDOTHELIN EXCRETION

我们研究了：1)高胰岛素血症对血浆和 尿ET水平；2)钠摄入量对ET排泄的影响 (UETV)在正常情况下和对高胰岛素血症的反应；3) UETV与尿钠、尿流量的关系这个 使用由DeFronzo博士开发的正常血糖胰岛素钳夹技术， 评估胰岛素抵抗的程度，并提供可控的 高胰岛素状态。 到目前为止，我们只研究了11名血压正常的受试者。 高胰岛素血症持续增加尿内皮素排泄量 但并不是很重要。最大的增长是在以下对象中观察到的 高钠饮食。这一效应伴随着显著的增长。 在尿流中。UETV和两者之间有很强的相关性 尿流率和尿钠。相比之下，无论是胰岛素输注，还是 钠摄入量的变化也不会显著影响血浆中的 ET或ANF。

We investigated: 1) The effects of hyperinsulinemia on plasma and urinary levels of ET; 2) The effects of sodium intake on ET excretion (UETV) under normal conditions and in response to hyperinsulinemia; 3) The correlations between UETV and urinary sodium and flow. The euglycemic insulin clamp technique, developed by Dr. DeFronzo, was used, to assess the degree of insulin resistance and provide a controlled hyperinsulinemic state. So far we have studied only eleven normotensive subjects. Hyperinsulinemia increased urinary excretion of endothelin consistently but not significantly. The largest increase was observed in subjects on a high sodium diet. This effect was accompanied by significant increases in urinary flow. There were strong correlations between UETV and both urinary flow and urinary sodium. In contrast, neither insulin infusion nor changes in sodium intake significantly affected plasma levels of either ET or ANF.