HYPERINSULIMEMIA AND ENDOTHELIN EXCRETION

高胰岛素血症和内皮素排泄

• 批准号: 3757675
• 负责人: H KLEIN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757675
• 关键词: dietary sodium; endothelin; excretion; human subject; hyperinsulinism; nutrition related tag; plasma; saluresis; urination; urine

We investigated: 1) The effects of hyperinsulinemia on plasma and urinary levels of ET; 2) The effects of sodium intake on ET excretion (UETV) under normal conditions and in response to hyperinsulinemia; 3) The correlations between UETV and urinary sodium and flow. The euglycemic insulin clamp technique, developed by Dr. DeFronzo, was used, to assess the degree of insulin resistance and provide a controlled hyperinsulinemic state. So far we have studied only eleven normotensive subjects. Hyperinsulinemia increased urinary excretion of endothelin consistently but not significantly. The largest increase was observed in subjects on a high sodium diet. This effect was accompanied by significant increases in urinary flow. There were strong correlations between UETV and both urinary flow and urinary sodium. In contrast, neither insulin infusion nor changes in sodium intake significantly affected plasma levels of either ET or ANF.

我们研究了：1）高胰岛素血症对血浆和 尿ET水平; 2）钠摄入对ET排泄的影响 （UETV）在正常条件下和响应于高胰岛素血症; 3） UETV与尿钠、尿流量的相关性。 的 使用DeFronzo博士开发的正葡萄糖胰岛素钳夹技术， 评估胰岛素抵抗的程度，并提供一个受控的 高胰岛素血症 到目前为止，我们只研究了11名血压正常的受试者。 高胰岛素血症持续增加内皮素的尿排泄 但不显著。 观察到的最大增幅是 高钠饮食 这种影响伴随着显著增加 在尿流中。 UETV和两者之间存在很强的相关性， 尿流量和尿钠。 相反，胰岛素输注 钠摄入量的变化也不显著影响血浆中 无论是ET还是ANF。