ROLE OF ANGIOTENSIN II ON REGULATION OF ENDOTHELIN EXCRETION

血管紧张素 II 对内皮素排泄的调节作用

• 批准号: 3843360
• 负责人: H KLEIN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843360
• 关键词: angiotensin II; blood pressure; drug administration rate /duration; endothelin; hormone regulation /control mechanism; human subject; phenylephrine; urination

Endothelin (ET), a recently discovered peptide, has been found to be the most potent vasoconstrictor known to men. It is found in high amounts in the urine compared to low levels in the plasma. Although much has been learned about the structure and biological effects of ET, little is known about the regulation of its urinary excretion (UETV). We are investigating 1) the effects of angiotensin II (AII) and Phenylephrine (PHE) on the UETV in normal volunteers. We started AII infusion at a rate of 3 ng/kg/min and titrated to an increase in mean arterial blood pressure of at least 20 mmHg for 60 minutes. The amount of AII required averaged 11.7 ng.kg/min. After a washout period, PHE was started at a rate of 1 mug/kg/min and titrated to same target blood pressure. The average PHE required was 2.5 mug/kg/min. AII roughly doubled urine flow (UV) and UETV in the initial 30 minutes, dropping back to baseline level in the last 30 minutes. PHE roughly increased urine flow by 8 fold and UETV by 7 fold in the first 30 minutes returning to close to baseline in the final 30 minute period.

内皮素(ET)是一种新近发现的多肽，被发现是 是男人已知的最有效的血管收缩药。它的含量很高，在 尿液与血浆中的低水平进行比较。尽管已经有了很多 关于ET的结构和生物学效应，人们知之甚少 关于其尿液排泄的调节(UETV)。 我们正在研究1)血管紧张素II(AII)和 正常人UETV上的苯肾上腺素(Phe) 我们以3纳克/公斤/分钟的速度开始所有输液，并滴定到 60岁平均动脉压至少增加20毫米汞 几分钟。所需的所有III量平均为11.7ng.kg/min。在.之后 洗脱期，Phe以1杯/公斤/分钟的速度启动，并滴定到 目标血压相同。平均所需的Phe为2.5ug/kg/min。 在最初的30分钟内，所有人的尿流率(UV)和UETV大致增加了一倍， 在最后30分钟内回落到基线水平。Phe大致 头30分钟尿流率增加8倍，UETV增加7倍 在最后30分钟内回到接近基线的水平。