HYPERINSULIMEMIA AND ENDOTHELIN EXCRETION

高胰岛素血症和内皮素排泄

• 批准号: 3779591
• 负责人: H KLEIN
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3779591
• 关键词: endothelin; essential hypertension; glucose metabolism; human subject; hyperinsulinism; insulin receptor; saluresis

Resistance to the action of Insulin on glucose metabolism, with ensuing compensatory hyperinsulinemia, is closely linked to essential hypertension. The decreased insulin sensitivity observed in hypertensive patients is present in both obese and non-obese subjects. Hyperinsulinemia has been found to increase sodium and water retention by the kidneys and to increase circulating levels of norepinephrine. It has also been shown to increase blood pressure by some authors, but not others. On the other hand, endothelin (ET), is a potent endogenous vasoconstrictor, produced by the endothelium. It is found in small amounts in plasma, compared to high levels in urine. Despite many studies in the literature on the subject, the roles played by ET and hyperinsulinemia in essential hypertension are still unclear. We are investigating: 1) the effects of hyperinsulinemia on blood pressure and on urinary excretion of endothelin (UETV) in normal volunteers and in salt sensitive and salt resistant hypertensive subjects. The euglycemic insulin clamp technique, developed by Dr. DeFronzo, is being used, to assess the degree of insulin resistance and provide a controlled hyperinsulinemic state.

胰岛素对葡萄糖代谢作用的抵抗， 代偿性高胰岛素血症，是密切相关的基本 高血压高血压患者胰岛素敏感性降低 患者存在于肥胖和非肥胖受试者中。 高胰岛素血症已被发现增加钠和水的保留 并增加去甲肾上腺素的循环水平。它 也被一些作者证明会增加血压，但不是 他人另一方面，内皮素（ET）是一种强有力的内源性 血管收缩剂，由内皮细胞产生。它被发现在小 与尿液中的高水平相比，血浆中的含量较高。尽管许多研究 在有关这一主题的文献中，ET和 原发性高血压高胰岛素血症尚不清楚。 我们正在研究：1）高胰岛素血症对血液的影响 血压和尿内皮素排泄（UETV）的正常 志愿者和盐敏感性和盐抵抗性高血压 科目正葡萄糖胰岛素钳夹技术，由Dr。 DeFronzo被用来评估胰岛素抵抗的程度， 提供受控的高胰岛素血症状态。