PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES

先天性异常的产前诊断

• 批准号: 3756773
• 负责人: R ROMERO
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3756773
• 关键词: congenital disorders; cystoscopy; diagnosis design /evaluation; diagnosis quality /standard; embryo /fetus surgery; endoscopy; hemodynamics; human pregnant subject; noninvasive diagnosis; prenatal diagnosis; ultrasonography; ultrasound blood flow measurement

The focus of this project is to improve the diagnosis and treatment of fetal disease. Focus is placed on the prenatal diagnosis of congenital anomalies with non-invasive methods (e.g. high resolution ultrasound and color Doppler flow mapping). The most significant contribution of the Branch was the performance of the first successful endoscopic surgical procedure in the human fetus. Transabdominal thin-gauge fetoscopy was used to cystoscopically fulgurate posterior urethral valves in a case of urethral obstruction. This procedure represents a new approach to the treatment of selected fetal congenital anomalies, as well as placental conditions amenable to surgical treatment. The Branch used high resolution ultrasound to establish prenatal diagnosis of conditions heretofore undiagnosed sonographically (e.g. nonrhizomelic chondrodysplasia punctata). Color Doppler flow mapping improved the accuracy of prenatal diagnosis of several other conditions suspected by sonography. The goal of the Branch is to expand the diagnostic and therapeutic indications of embryofetoscopy, as well as the diagnostic capability of high resolution ultrasound and color Doppler flow mapping.

该项目的重点是改善疾病的诊断和治疗 胎儿疾病。重点关注先天性疾病的产前诊断 通过非侵入性方法（例如高分辨率超声和 彩色多普勒血流图）。 该分行最重要的贡献是其业绩 首次成功对人类胎儿进行内窥镜手术。 经腹薄规格胎儿镜用于膀胱镜电灼 尿道梗阻时的后尿道瓣膜。这 该程序代表了一种治疗选定胎儿的新方法 先天性异常，以及适合手术治疗的胎盘状况 治疗。 该科使用高分辨率超声进行产前诊断 迄今为止未通过超声诊断的病症（例如非根茎部 点状软骨发育不良）。彩色多普勒血流图改善了 怀疑的其他几种情况的产前诊断的准确性 超声检查。 该分会的目标是扩大诊断和治疗范围 胚胎胎儿镜检查的适应症以及诊断能力 高分辨率超声和彩色多普勒血流图。