THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION

亚临床感染和细胞因子在早产中的作用

• 批准号: 3842422
• 负责人: R ROMERO
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3842422
• 关键词: amnion; birth; cellular pathology; cervix disorder; child (0-11); disease /disorder prevention /control; female; human pregnant subject; human subject; interleukin 1; interleukin 6; interview; molecular pathology; pregnancy infection; premature labor; prognosis; tumor necrosis factor alpha

The objectives of this project are to define the role of ascending intrauterine infection in the etiology of preterm labor and delivery, to elucidate the cellular and molecular mechanisms signalling preterm parturition in the setting of infection and to apply this knowledge to improve the diagnostic and therapeutic approach to preterm labor. Clinical investigation has focused on determining the frequency and clinical significance of microbial invasion of the amniotic cavity in patients with preterm labor, preterm premature rupture of membranes, cervical incompetence and normal labor at term. We have established the value and limitations of different rapid laboratory tests in the diagnosis of microbial invasion of the amniotic cavity and in the prediction of preterm delivery. Laboratory investigation has focused on the study of macrophage cytokines (interleukin-1, tumor necrosis factor, interleukin-6) on the mechanisms of human parturition associated with infection, the development of an animal model for ascending intrauterine infection and the study of the role of anticytokine agents (interleukin-I natural receptor antagonist and tumor necrosis factor antagonists) in preventing infection induced preterm delivery.

这个项目的目标是定义上升的角色 宫内感染在早产和分娩病因中的作用， 阐明早产信号传导的细胞和分子机制 在感染的情况下分娩，并将这些知识应用于 改善早产的诊断和治疗方法。 临床研究的重点是确定频率和 羊膜腔微生物浸润的临床意义 早产、早产胎膜早破、 宫颈机能不全和正常分娩 我们成立了 不同的快速实验室检测方法的价值和局限 诊断微生物侵入羊膜腔和 预测早产。 实验室研究主要集中在巨噬细胞的研究上 细胞因子（白细胞介素-1，肿瘤坏死因子，白细胞介素-6）对 与感染相关的人类分娩机制， 建立上行性宫内感染动物模型， 研究抗细胞因子药物（白细胞介素-I天然） 受体拮抗剂和肿瘤坏死因子拮抗剂）在预防 感染导致早产。