PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
批准号:
5203392
负责人:
R ROMERO
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
cardiovascular disorder diagnosis congenital disorders cystoscopy diagnosis design /evaluation diagnosis quality /standard embryo /fetus embryo /fetus surgery endoscopy hemodynamics human pregnant subject noninvasive diagnosis portal vein prenatal diagnosis ultrasonography ultrasound blood flow measurement
中文摘要
本项目的重点是提高诊断和治疗
英文摘要
The focus of this project is to improve the diagnosis and treatment of
fetal disease. Focus is placed on the prenatal diagnosis of congenital
anomalies with non-invasive methods (e.g., high resolution ultrasound and
color Doppler flow mapping) and invasive methods.
The Branch pioneered the utilization of thin-gauge endoscopy in the
differential diagnosis of fetal obstructive uropathy. Fetuses with
sonographic findings of lower obstructive uropathy are a diagnostic and
therapeutic challenge. Ultrasound imaging alone cannot establish the
cause of the obstruction and treatment with percutaneous vesicoamniotic-
shunts has a complication rate of 25%. We inserted a fiberoptic
endoscope through the lumen of the needle (or trocar) placed into the
fetal bladder and visualized the bladder neck and ureteral orifices.
Eleven fetal cystoscopies were performed successfully. Ureteral webs were
noted in two fetuses. A catheter was passed from the fetal bladder into
the amniotic cavity in two cases to treat the obstruction. Ureteral
probing with a flexible catheter was sufficient to treat the obstruction
in other cases. This impressive technological achievement is a landmark
in fetal medicine and surgery.
High resolution ultrasound was used to establish the prenatal diagnosis
of congenital anomalies in the cardiovascular system. Color Doppler flow
mapping has improved the accuracy of prenatal diagnosis of several other
conditions which could only be suspected by gray-scale sonography.
During the past year, the investigators of the Branch reported the first
diagnosis of agenesis of the right and left portal veins. The Branch
also described a diagnostic approach for the identification of
coarctation of the aorta with the aid of color-flow Doppler ultrasound.
Color flow mapping studies of the fetal circulation allowed the
identification of fetuses with reversal of blood flow in the ductus
venosus. The prevalence of this condition was 2.4% and perinatal death
occurred in all 5 fetuses with reversal of diastolic flow in the ductus
venosus. The hemodynamic mechanisms responsible for reversal of flow
appeared to increase pressure in the left atrium and diastolic heart
failure.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:5203391
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
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批准号:3756773
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:2575744
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:3778673
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:3778674
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:3842422
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
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批准号:2575745
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:6162520
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
PRENATAL DIAGNOSIS OF CONGENITAL ANOMALIES
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批准号:6162521
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION
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批准号:3756772
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R ROMERO
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依托单位:
海外基金