LIP_Real-time moLecular dIagnosis of Oral Precancer

口腔癌是严重的限制生命的疾病，特别是在晚期诊断时。在癌前病变（不典型增生）或早期癌症阶段尽早发现是降低口腔癌患者死亡率的唯一最重要的措施。LIP的目标是探索一种新的极化拉曼技术在体内实时口腔癌前诊断的创新潜力。偏振拉曼光谱是一种无标记的光学技术，可以提供组织结构/分子对称性和组成的点向振动分子指纹“光学活检”。LIP将通过最先进的极具创造性的极化拉曼专利技术和源自ERC研究的数据驱动人工智能的结合，在医学上提供即时的技术应用。为了满足未满足的临床需求，LIP促进了40例患者的口腔极化拉曼光谱在体内癌前诊断中的首次临床试验演示和验证。数据驱动的人工智能将使拉曼光谱的速度提高约50%，并创建强大的概率算法，用于在100毫秒内实时诊断口腔癌前病变。lip为技术开发奠定了基础，并概述了临床验证和原型实施计划。总之，这些活动将为无标签微创诊断和未来的商业化机会提供更广阔的市场切入点。

Oral cancers are severe life-limiting diseases, particularly when diagnosed in the later stages. Earliest possible detection in precancer (dysplasia) or early cancer stages is the single most important measure for reducing oral cancer patients' mortality rates. The goal of LIP is to explore the innovative potential of a new polarized Raman technique for in vivo real-time oral precancer diagnosis. Polarized Raman spectroscopy is a label-free optical technique that can provide a point-wise vibrational molecular fingerprint "optical biopsy" of both tissue structure/molecular symmetries and composition.LIP will deliver immediate technological application in medicine via beyond state-of-the-art highly inventive combination of a patented polarized Raman technology and data driven AI originating from ERC research. To meet the unmet clinical need LIP facilitates the first clinical trial demonstration and validation of polarized Raman spectroscopy in the oral cavity for in vivo precancer diagnostics in 40 patients. Data driven AI will be used empower Raman spectroscopy with ~x50 improvement in speed and create robust probabilistic algorithms for real-time diagnosis of oral precancers within 100 ms.LIP lays the groundwork for technological exploitation and outlines a programme of clinical validation and prototype implementation. Altogether, these activities will provide an entry point in the broader market for label-free minimally invasive diagnostics and future commercialisation opportunities.