HONOLULU AGING STUDY

NIA补充了由NHLBI和NIA赞助的一个研究项目 通过NHLBI与Kuakini医疗中心的合同提供支持 夏威夷檀香山，允许对老年人和痴呆症进行研究 研究参与者。火奴鲁鲁心脏计划(HHP)是一个 美国日裔男性心血管疾病的研究 1900年至1919年出生，1965年居住在瓦胡岛。这 研究的重点将是衰老，重点是阿尔茨海默氏症和 多发性梗死性痴呆。大约4,600马力中的约3,800马力 到目前为止，已经联系了参与者，包括大约 已接受全部或几乎所有标准考试的3500人 还有采访。大约20到25分钟的NHLBI考试 致力于NIA数据收集，包括管理 认知能力和筛查工具(CASI)和问卷 以获取有关痴呆症可能的危险因素的信息。 约13%的受试者被邀请回来参加 后续检查。被邀请回来的人包括所有 CASI得分较低的参与者，约33% 获得临界值(74-82，N=176)，7%的人获得 CASI评分正常(大于82分，N=165)。这次通话的目的是- 背部检查是对痴呆症进行高度标准化的检查 按照先前商定的指导方针进行评价，并根据这些准则 算法痴呆症分类可以使用 最低限度的主观解读和临床判断。

The NIA supplements a research project sponsored by the NHLBI and supported through an NHLBI contract with Kuakini Medical Center in Honolulu, Hawaii, to allow for research on aging and dementia among study participants. The Honolulu Heart Program (HHP) is a prospective study of cardiovascular diseases of American men of Japanese ancestry born from 1900 to 1919 and living on the island of Oahu in 1965. This study will focus on aging, with the emphasis on Alzheimer's disease and multi-infarct dementia. About 3,800 of the approximately 4,600 HHP participants have been contacted thus far, including approximately 3,500 who have received all or almost all of the standard examination and interview. Approximately 20 to 25 minutes of the NHLBI examination is devoted to NIA data collection, including administration of the Cognitive Abilities and Screening Instrument (CASI) and a questionnaire to elicit information concerning possible risk factors for dementia. Approximately 13% of the examined participants were invited back for a follow-up examination. Those invited back include all of the participants who receive low CASI scores, about 33% of those who received borderline scores (74-82, N=176), and 7% of those who received normal (greater than 82, N=165) CASI scores. The purpose of this call- back examination is to carry out a highly standardized dementia evaluation following guidelines previously agreed upon and from which an algorithmic dementia classification can be accomplished with a minimum of subjective interpretation and clinical judgement.