CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

这个药物滥用研究中心包括一个核心和八个 主要项目分为三个部门，用于药物开发： 1.临床前神经生物学；2.人体实验室研究；3.临床 审判。 核心刺激了可卡因神经生物学和可卡因的新方法 通过协调整个精神病学的研究努力进行药物治疗， 药理学、核医学和检验医学。它已经发展成 当前中心提案中的创新研究想法(例如收购 飞行员，可卡因提示反应性，动物的位置偏好)，以及 投入后来独立资助的项目(例如艾滋病毒痴呆症， 氟苯硫醇、美沙酮中的地昔帕明)。核心资源拥有 还为学员的研究提供了技术和物质上的帮助 导致独立资助研究的项目(例如，mazindol 飞行员，金刚烷胺飞行员)。拟议的核心试点研究(例如 酒精性可卡因滥用者、焦虑症和可卡因患者的双硫兰) 应该延续这一传统。 八个主要项目中有三个是我们先前工作的延续： 1.可卡因戒断的神经生物学，2.可卡因在 维持药物疗法，3.可卡因的代谢研究，重点是 可卡因与酒精的相互作用。另一个原始中心 项目导致了独立资助的赠款，如目前的三个项目 丁丙诺啡研究，不再需要中心的资助。五个新的 从核心试点工作演变而来的项目：1.动物模型到筛选 药物治疗和了解可卡因的分子机制 行为，2.刺激剂对多巴胺神经生物学影响的SPECT成像 灵长类动物与人类，3.可卡因线索反应性的人体实验室研究 在神经递质操作和维护期间 药物治疗，以及4，5.布维酮和安非他明的临床试验 卡马西平。增加了两个新的临床站点，以增加 调查员和研究对象池：West Haven V.A.和The 康涅狄格大学。因此，既延续了我们目前的中心 和主要的新启蒙者朝着基础广泛的药物开发 计划已被纳入我们研究的继续 中心。

This center for Research on Substance Abuse includes a Core and eight major projects organized into three Divisions for medication development: 1. preclinical neurobiology, 2. human laboratory studies and 3. clinical trials. The Core has stimulated novel approaches to cocaine neurobiology and pharmacotherapy by coordinating research efforts across Psychiatry, Pharmacology, Nuclear Medicine and Laboratory Medicine. It has developed innovative research ideas into current Center proposals (e.g. buproprion pilot, cocaine cue reactivity, place preference in animals), as well as into projects that were later independently funded (e.g. HIV dementia, flupenthixol pilot, desipramine in methadone pilot). Core resources have also provided technical and material assistance in trainee' research projects that have led to independently funded research (e.g. mazindol pilot, amantadine pilot). Proposed pilot studies in the Core (e.g. disulfiram for alcoholic cocaine abusers, anxiety disorders and cocaine) should continue this tradition. Three of the eight major projects are continuations of our previous work: 1. the neurobiology of cocaine withdraw, 2. cocaine challenges during maintenance pharmacotherapies, 3. metabolic studies of cocaine focusing on the interaction of cocaine with alcohol. The other original Center projects have led to independently funded grants such as the three current buprenorphine studies, and no longer need Center funding. Five new projects evolved from Core pilot work: 1. animal models to screen medications and to understand the molecular mechanisms of cocaine's actions, 2. SPECT imaging of stimulant effects on dopamine neurobiology in primates and humans, 3. human laboratory studies of cocaine cue reactivity during neurotransmitter manipulation and during maintenance pharmacotherapy, and 4,5. clinical trials with buproprion and carbamazapine. Two new clinical sites have been added to increase the investigator and subject pools for studies: West Haven V.A. and the University of Connecticut. Thus, both continuity with our current Center and major new initiates towards a broad based medication development program have been incorporated into the continuation of our Research Center.