Great Lakes Node of the Drug Abuse Clinical Trials Network

项目摘要/摘要 根据RFA-DA-19-008，本申请寻求建立 NIDA支持的药物滥用临床试验网络(CTN)。该节点将利用一组经验丰富的 积极合作并代表美国所有主要学术医学中心的研究人员 大芝加哥和威斯康星州地区。该节点将作为CTN的重要中西部枢纽，并将 详述CTN方法的成功之处。此外，GLN将在以下方面带来丰富的经验 青少年/青年研究、老年人/老龄化研究、数字和移动技术、阿片滥用、 协作性护理/人口健康、远程保健、电子健康记录和系统驱动的干预 和研究方法。 GLN将支持与CTN协议接洽，并添加以下内容： 目标1：GLN将识别和推荐侧重于以下方面的物质滥用研究和干预方案 使用基于医院的筛查、协作护理和人口方法的基于系统的实践。 目标2：我们将建立一个数字和计算健康核心，利用我们在这些领域的专业知识 并作为研究mHealth、eHealth、人工智能、自然语言处理和 远程医疗干预。 目标3：我们的节点将带来青年/青少年健康和老年人/老龄化方面的大量专业知识，从而实现 美国向CTN推荐研究物质滥用的根源和潜在的 预防战略，以缓解这些生命过程的途径。 目标4：根据我们团队的专业知识，我们计划支持关于物质和阿片类药物滥用的工作 重点关注健康差距，包括社会经济、地理、性取向和性别认同。 目标5：利用我们在专业教育和实践性学习方面的经验，我们的节点将 严格测试专业教育对阿片类药物和物质治疗的影响。我们建立在 Echo模式，以开发方法来开展高质量的远程教育和支持培训，这些培训 目前正在伊利诺伊州进行试验，计划在全国范围内推广这些项目。 目标6：Gln将扩大对物质滥用研究感兴趣的早期调查人员的渠道。我们会 使我们计划的这一部分与我们非常成功的CTSA支持计划保持一致，并构建特定的 支持成瘾和物质滥用研究、培训和指导的子规划。

Project Summary/Abstract In alignment with RFA-DA-19-008, this application seeks to establish the Great Lakes Node (GLN) of the NIDA-supported Drug Abuse Clinical Trials Network (CTN). This node will draw on an experienced set of investigators who have active collaborations and represent all of the major academic medical centers in the Greater Chicago and Wisconsin areas. The node will serve as a vital Midwestern hub for the CTN and will expand on the success of the CTN approach. In addition, the GLN will bring substantial experience in adolescent/young adult research, seniors/aging research, digital & mobile technologies, opioid misuse, collaborative care/population health, telehealth, and electronic health record and systems-driven interventions and research methodologies. The GLN will support engagement with CTN protocols and also add the following: Aim 1: GLN will identify and recommend substance misuse research and intervention protocols focused on systems-based practice using hospital-based screening, collaborative care, and population approaches. Aim 2: We will establish a digital and computation health core that will leverage our expertise in these domains and serve as a conduit for studies in mHealth, eHealth, artificial intelligence, natural language processing, and telehealth interventions. Aim 3: Our node will bring substantial expertise with youth/adolescent health and seniors/aging that will enable us to recommend studies to the CTN that examine the genesis of substance misuse and the potential for prevention strategies to mitigate these life-course pathways. Aim 4: In alignment with our team’s expertise, we plan to support work on substance and opioid misuse that focuses on health disparities including socioeconomic, geographic, sexual orientation, and gender identity. Aim 5: Leveraging our experience in professional education and practice-based learning, our node will rigorously test the impact of professional education on opioid and substance treatment. We have built on the ECHO model to develop methods to conduct high-quality distance education and supported training that are currently being trialed in Illinois with plans to expand these programs nationally. Aim 6: GLN will expand the pipeline of early investigators interested in substance misuse research. We will align this part of our program with our very successful CTSA-supported programs and build specific subprogramming that supports addiction and substance misuse research, training, and mentorship.