The ANTIDOTE Institute- Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts

ANTIDOTE Institute - 推动新毒理学研究人员在药物滥用和原创转化研究工作中的发展

• 批准号: 10681927
• 负责人: STEPHANIE P CARREIRO
• 金额: $ 30.2万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10681927
• 关键词: Acceleration; Address; Adverse drug event; American; Awareness; Behavioral; Behavioral Sciences; Board Certification; Career Mobility; Caring; Clinical; Collaborations; Data; Dedications; Development; Diagnosis; Discipline; Drug abuse; Education Gap; Educational Curriculum; Epidemic; Epidemiology; Evaluation; Faculty; Funding; Goals; Grant; Group Meetings; Health; Health system; Hybrids; Instruction; Investigation; Learning; Learning Skill; Measures; Medical; Medicine; Mental disorders; Mentors; Mentorship; Methodology; Modeling; National Institute of Drug Abuse; Patient Care; Patients; Persons; Pharmaceutical Preparations; Pharmacotherapy; Physicians; Poison; Poisoning; Population; Positioning Attribute; Program Development; Program Evaluation; Public Health; Reaction; Records; Research; Research Methodology; Research Personnel; Role; Scientist; Structure; Substance Use Disorder; Substance of Abuse; Therapeutic Uses; Toxicology; Training; Training Programs; Translating; Translational Research; Trauma; United States; Writing; behavior change; career; cohort; comorbidity; experience; innovation; interdisciplinary approach; interest; knowledge translation; medical schools; medical specialties; meetings; member; multidisciplinary; next generation; novel therapeutics; outreach; pharmacokinetics and pharmacodynamics; pharmacologic; programs; recruit; research and development; response; satisfaction; skill acquisition; skills; social stigma; success; theories; tool; virtual; virtual group

PROJECT SUMMARY/ABSRACT This proposal is responsive to PAR-21-320 with two overarching goals: 1) to provide empiric training in research methodology and hypothesis-driven research, and 2) to train a diverse cadre of clinical medical toxicologists as independent researchers at the intersection of substance use disorder (SUD) and public health. The epidemics of SUD are in sore need of innovation and diversity among researchers. Medical Toxicology is a field of medicine dedicated to the evaluation and treatment of poisoned patients, including adverse health effects of drugs and illicit substances. Medical toxicologists have a track record of innovation and public health-relevant research in SUD; however, few pursue careers as independent, federally funded investigators. In response to this gap in our specialty, we developed in collaboration with the American College of Medical Toxicology, a hybrid research mentorship program, the ANTIDOTE (Advancing New Toxicology Investigators in Drug abuse and Original Translational research Efforts) Institute. The ANTIDOTE Institute provides structured research methodology training and mentorship to medical toxicologists with a long-term goal of developing a pipeline of medical toxicology physician scientists that achieve independent federal funding in SUD research. This R25 proposes to formalize ANTIDOTE by extending our curriculum for a more rigorous training experience, providing seed funding to accelerate the progress of institute fellows in SUD research, and expanding institute activities to include outreach and multi-generational mentorship. The expanded two-year ANTIDOTE curriculum will be delivered using a hybrid approach including in-person retreats, virtual group meetings/didactics, and virtual one-on-one meetings. We have assembled a strong multi- disciplinary faculty who are experts in research methodology, innovators in the care of SUD, and master educators. The Specific Aims of this proposal are: 1) To expand, implement and widely disseminate the ANTIDOTE institute with a curriculum grounded in Participatory Learning Theory to support the development of toxicologists as clinician scientists: 2) To evaluate the impact of the ANTIDOTE institute using a validated program evaluation tools: and 3) To facilitate and sustain the development of a diverse investigator pipeline in medical toxicology, through training in mentorship skills, knowledge translation and outreach. The ANTIODTE Institute is the first program of its kind to systematically address educational gaps within medical toxicology training around developing hypothesis-driven research investigations. Successful expansion of the program will facilitate methodologically rigorous and clinically informed research on SUD and create a national network of diverse investigators to sustain this momentum. This framework can then be translated outside of the field of medical toxicology to facilitate pipeline development in other clinical specialties.

项目概要/摘要 本建议是对PAR-21-320的回应，有两个总体目标：1）提供以下方面的经验培训： 研究方法和假设驱动的研究，2）培养多样化的临床医学骨干 毒理学家作为物质使用障碍（SUD）和公众交叉点的独立研究人员 健康SUD的流行迫切需要研究人员的创新和多样性。医疗 毒理学是一个致力于评估和治疗中毒患者的医学领域，包括 毒品和非法物质对健康的不良影响。医学毒理学家有创新的记录 和公共卫生相关的研究在南加州大学;然而，很少有人追求事业作为独立的，联邦政府资助的 investigators.为了应对我们专业的这一差距，我们与美国合作开发了 医学毒理学学院，一个混合研究导师计划，ANTIDOTE（推进新 药物滥用毒理学研究者和原始转化研究工作）研究所。解药 研究所为医学毒理学家提供结构化的研究方法培训和指导， 长期目标是建立一个医疗毒理学医生科学家的管道， 联邦基金在SUD研究。这个R25建议通过扩展我们的课程， 更严格的培训经验，提供种子资金，以加快研究所研究员在南德意志大学的进展 研究，并扩大研究所的活动，包括外联和多代辅导。的 扩展的两年制ANTIDOTE课程将采用混合方法提供，包括面对面 务虚会、虚拟小组会议/教学法和虚拟一对一会议。我们已经建立了一个强大的多- 学科教师谁是研究方法的专家，在SUD的护理创新者，和硕士 教育工作者这项建议的具体目标是：（1）扩大、执行和广泛传播 ANTIDOTE研究所的课程以自主学习理论为基础，以支持 毒理学家作为临床科学家：2）使用经验证的 项目评估工具：以及3）促进和维持多样化研究者管道的发展， 通过指导技能培训、知识转化和外联，加强医学毒理学。Antiodte 该研究所是第一个系统地解决医学毒理学教育差距的项目 围绕开发假设驱动的研究调查进行培训。该计划的成功扩展将 促进对SUD进行方法上严格和临床上知情的研究，并建立一个全国性的网络， 不同的研究人员来维持这一势头。然后，这个框架可以在 医学毒理学，以促进其他临床专业的管道开发。