POSTMENOPAUSAL ESTROGEN/PROGESTIN INTERVENTIONS

绝经后雌激素/孕激素干预

• 批准号: 3553189
• 负责人: CARL JOSEPH PAUERSTEIN
• 金额: $ 13.05万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553189
• 关键词: blood pressure; clinical trials; combination chemotherapy; cooperative study; disease /disorder proneness /risk; estrogens; female; fibrinogen; heart disorder; hormone therapy; human subject; human therapy evaluation; insulin; medroxyprogesterone; osteoporosis; postmenopause; progestins

To establish a Clinical Core at the University of Texas Health Science Center in San Antonio. The San Antonio Clinical Center will recruit 150 peri- and postmenopausal women in a period not to exceed 12 months. We propose to compare the effects of oral estrogen treatments in the presence and in the absence of micronized progesterone. proposed primary outcome parameters include evaluation of: endometrial histology, lipid and glucose metabolism, and symptomatology. Other suggested outcome parameters include cardiovascular effects, effects on coagulation, effects on gallbladder disease and effects on bone density.

在德克萨斯大学健康科学学院建立临床核心 在圣安东尼奥中心。 圣安东尼奥临床中心将招募150名 绝经期和绝经后妇女，时间不超过12个月。 我们 建议比较口服雌激素治疗的效果， 并且不存在微粒化孕酮。 拟定的主要结局 参数包括评价：子宫内膜组织学、血脂和血糖 代谢和代谢学。 其他建议的结果参数包括 心血管效应、对凝血的影响、对胆囊的影响 疾病和影响骨密度。