POSTMENOPAUSAL ESTROGEN/PROGESTIN INTERVENTIONS

绝经后雌激素/孕激素干预

• 批准号: 3553187
• 负责人: CARL JOSEPH PAUERSTEIN
• 金额: $ 30.53万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3553187
• 关键词: blood coagulation; blood glucose; blood lipid; bone density; cholelithiasis; combination chemotherapy; cooperative study; coronary disorder; disease /disorder proneness /risk; drug administration routes; endometrium; estrogens; female; histology; hormone therapy; human subject; human therapy evaluation; osteoporosis; postmenopause; progesterone; progestins

This application is written in response to RFA NIH 87-IHL-06-H - Postmenopausal Estrogen/Progestin Interventions (PEPI). We propose to establish a Clinical Center at the University of Texas Health Science Center in San Antonio. The San Antonio Clinical Center will recruit 150 eligible peri and postmenopausal women in a period not to exceed 12 months. We propose to compare the effects of oral versus transdermal estrogen treatment, in the presence and in the absence of micronized progesterone. Proposed primary outcome parameters include evaluation of: endometrial histology, lipid and glucose metabolism, and symptomatology. Other suggested outcome parameters include cardiovascular effects, effects on coagulation, effects on gallbladder disease and effects on bone density.

本申请是根据RFA NIH87-IHL-06-H- 绝经后雌激素/孕激素干预(PEPI)。我们 建议在德克萨斯大学建立一个临床中心 圣安东尼奥的健康科学中心。圣安东尼奥诊所 中心将招募150名符合条件的围绝经期和绝经后妇女 不超过12个月的期限。我们建议将 口服与透皮雌激素治疗的疗效比较 在没有微粒化黄体酮的情况下。 拟议的主要成果参数包括评价： 子宫内膜组织学，脂肪和葡萄糖代谢，以及 症状学。其他建议的结果参数包括 心血管效应，对凝血的影响，影响 胆囊病及其对骨密度的影响。