POSTMENOPAUSAL ESTROGEN/PROGESTIN INTERVENTIONS

本申请是根据RFA NIH 87-IHL-06-H编写的， 绝经后雌激素/孕激素干预（PEPI）。 我们 建议在德克萨斯大学建立临床中心 圣安东尼奥的健康科学中心。 圣安东尼奥诊所 中心将招募150名符合条件的绝经期和绝经后妇女， 不超过12个月的期限。 我们建议比较 口服与经皮雌激素治疗的效果，在 存在和不存在微粒化孕酮。 拟定的主要结局参数包括评价： 子宫内膜组织学、脂质和葡萄糖代谢，以及 医学。 其他建议的结果参数包括 心血管效应，对凝血的影响，对 胆囊疾病和影响骨密度。

This application is written in response to RFA NIH 87-IHL-06-H - Postmenopausal Estrogen/Progestin Interventions (PEPI). We propose to establish a Clinical Center at the University of Texas Health Science Center in San Antonio. The San Antonio Clinical Center will recruit 150 eligible peri and postmenopausal women in a period not to exceed 12 months. We propose to compare the effects of oral versus transdermal estrogen treatment, in the presence and in the absence of micronized progesterone. Proposed primary outcome parameters include evaluation of: endometrial histology, lipid and glucose metabolism, and symptomatology. Other suggested outcome parameters include cardiovascular effects, effects on coagulation, effects on gallbladder disease and effects on bone density.