RAPID REPEAT MEASUREMENT OF RCBF WITH PET AND 0-15 WATER

使用 PET 和 0-15 水快速重复测量 RCBF

• 批准号: 3774466
• 负责人: P HERSCOVITCH
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3774466
• 关键词: brain disorder diagnosis; brain mapping; chickenpox; communicable disease control; communicable disease diagnosis; communicable disease transmission; deuterium oxide; diagnosis quality /standard; endonuclease; epidemiology; human subject; immunosuppression; nosocomial infections; positron emission tomography; radiology; serology /serodiagnosis; technology /technique; varicella zoster virus; virus DNA; virus classification; visual cortex

O-15 water, because of its short half-life, is widely used to perform multiple sequential rCBF measurements in one scan session, e.g., in functional mapping studies. Typically, one waits about 12 min to allow for decay of the background before performing the next scan. We have developed a method to perform sequential rCBF measurements more rapidly, by modifying the tracer kinetic equation to account for residual background in blood and brain from a previous scan. Simulation studies demonstrated that there is only a 2-3% increase in the noise in estimates of rCBF due to use of this method. Preliminary data have been obtained in subjects at rest and during visual stimulation, with intervals between 0-15 water injections of 6 min. The % correction in rCBF for residual background ranged from 6% in visual cortex to 17% in white matter. Software has been written to apply this method to PET images on a pixel- by-pixel basis. This will facilitate data analysis comparing the results of activation studies performed with this "fast water" approach to those obtained with the standard method. In addition, we plan to extend this method to semiquantitative 0-15 water studies, when tissue counts are used to map rCBF changes in activation studies. This approach to increase the frequency of rCBF measurements will provide greater flexibility in PET experiments such as brain mapping and studies of acute drug effects on rCBF. Also, it will make such studies easier for patients to tolerate. It will be useful in 3-D imaging studies of single-subjects, in which many more injections of smaller amounts of 0-15 water are used to increase signal-to-noise ratio.

O-15水，由于其半衰期短，被广泛用于执行 在一个扫描会话中的多个顺序的rCBF测量，例如，在 功能定位研究。 通常，人们等待大约12分钟， 在执行下一次扫描之前，背景的衰减。 我们有 开发了一种方法来更快速地执行顺序rCBF测量， 通过修改示踪剂动力学方程来解释残留的 血液和大脑的背景 模拟研究 表明，在估计中噪声仅增加2 - 3%， 由于使用这种方法，rCBF。 初步数据已经获得 在受试者休息时和视觉刺激期间， 0-15 6 min的水注射。 背景的范围从视觉皮层的6%到白色物质的17%。 已经编写了软件来将该方法应用于像素上的PET图像- 逐像素地。 这将有助于比较结果的数据分析 用这种"快水"方法进行的活化研究， 用标准方法得到的。 此外，我们还计划延长这一 方法进行半定量0 - 15水研究时， 用于绘制激活研究中的rCBF变化。 这种增加rCBF测量频率的方法将提供 PET实验的灵活性更大，例如脑映射和研究 急性药物对rCBF的影响。 此外，这将使这些研究更容易 患者可以忍受。 这将是有用的三维成像研究 单个受试者，其中更多注射少量0 - 15 使用水来增加信噪比。