DETERMINATION OF THE PARTITION COEFFICIENT OF 0-15 LABELLED WATER
0-15标记水分配系数的测定
基本信息
- 批准号:3874321
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Cercopithecidae blood brain barrier body water chickenpox communicable disease control communicable disease diagnosis communicable disease transmission computer assisted diagnosis deuterium diagnosis design /evaluation epidemiology human subject immunosuppression intraarterial administration model design /development nosocomial infections positron emission tomography radionuclide diagnosis radiotracer serology /serodiagnosis stimulus /response varicella zoster virus virus DNA virus classification
项目摘要
Methods of measuring regional cerebral blood flow (CBF) with PET and 0-15
water involve the use of two parameters, the flow and the partition
coefficient (p) for water, which is defined as the ratio of the tissue and
blood tracer concentrations at equilibrium. The value of p reflects the
relative solubility of the tracer in tissue and blood and can be calculated
as the ration of brain and blood water contents, using published.data for
these values. In some methods for measuring CBF and PET, this calculated
value is used in the mathematical formulation, and flow is calculated from
measured blood and tissue radioactivity. In alternative methods, values for
both flow and p are estimated from the measured data. With these methods,
the value of p was found to be lower than that predicted from the ratio of
brain and blood water contents.
To address this issue further, a method was developed to measure p directly
with PET and 0-15 water. IT involves constructing a radiotracer infusion
schedule which rapidly produces and sustains equilibrium between tissue and
blood. This method was used to measure p in baboons. Two injections of 0-15
water are required in each study: a blous i.v. injections from which the
arterial impulse response is obtained, and an 8 min designed infusion
administered by a computer-controlled pump. The value of p calculated as
the ratio of the tissue to blood concentrations from 3 to 8 min was 0.80
ml/g (0.006 SD, n=10). In addition, p was estimated with a pixel-by-pixel
least squares method from the full 8 min time course of brain and blood
radioactivity data; values were 0.76-0.78 ml/g. These results suggest that
the in vivo p as measured with PET within a short period following tracer
administration is smaller than the value (0.98 for gray matter, 0.90 for
whole brain) based on in vitro water contents of brain and blood. In order
to further explore this discrepancy, we will measure the value of p in
baboons with the above PET method.
PET 和 0-15 测量局部脑血流量 (CBF) 的方法
水涉及两个参数的使用:流量和分配
水的系数 (p),定义为组织和水的比率
平衡时的血液示踪剂浓度。 p 的值反映了
示踪剂在组织和血液中的相对溶解度,可以计算
作为大脑和血液含水量的比例,使用已发表的数据
这些值。在一些测量 CBF 和 PET 的方法中,这计算
值用于数学公式中,流量计算公式为
测量血液和组织的放射性。在替代方法中,值
流量和 p 都是根据测量数据估算的。通过这些方法,
发现 p 的值低于根据比率预测的值
脑和血液的水分含量。
为了进一步解决这个问题,开发了一种直接测量 p 的方法
用 PET 和 0-15 水。 IT 涉及构建放射性示踪剂输液
快速产生并维持组织和组织之间平衡的时间表
血。该方法用于测量狒狒的 p。 0-15 两次注射
每项研究都需要水:静脉注射。注射从中
获得动脉脉冲响应,并设计 8 分钟输注
由计算机控制的泵管理。 p 的值计算如下
3至8分钟组织浓度与血液浓度之比为0.80
毫升/克(0.006 SD,n=10)。另外,p是用逐像素估计的
大脑和血液的完整 8 分钟时间过程的最小二乘法
放射性数据;值为0.76-0.78ml/g。这些结果表明
示踪剂后短时间内用 PET 测量的体内 p
管理小于该值(灰质为 0.98,灰质为 0.90)
全脑)基于大脑和血液的体外水含量。为了
为了进一步探讨这种差异,我们将测量 p 的值
狒狒用上述PET方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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P HERSCOVITCH其他文献
P HERSCOVITCH的其他文献
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{{ truncateString('P HERSCOVITCH', 18)}}的其他基金
PET STUDIES OF HYPEROSMOTIC OPENING OF THE BLOOD-BRAIN BARRIER IN BABOONS
狒狒血脑屏障高渗打开的 PET 研究
- 批准号:
3874320 - 财政年份:
- 资助金额:
-- - 项目类别:
DESIGN OF FUNCTIONAL BRAIN MAPPING STUDIES WITH PET AND O-WATER
使用 PET 和 O-Water 进行功能性脑图谱研究的设计
- 批准号:
3752239 - 财政年份:
- 资助金额:
-- - 项目类别:
MEASUREMENT OF RCBF WITH PET UNDER NON-STEADY STATE CONDITIONS--ERROR ANALYSIS
非稳态条件下PET测量RCBF--误差分析
- 批准号:
3774467 - 财政年份:
- 资助金额:
-- - 项目类别:
RAPID REPEAT RCBF MEASUREMENT WITH POSITRON EMISSION TOMOGRAPHY AND O15 WATER
使用正电子发射断层扫描和 O15 水进行快速重复 RCBF 测量
- 批准号:
3853091 - 财政年份:
- 资助金额:
-- - 项目类别:
DETERMINATION OF RADIATION DOSIMETRY FOR PET RADIOPHARMACEUTICALS
宠物放射性药物辐射剂量测定
- 批准号:
2456696 - 财政年份:
- 资助金额:
-- - 项目类别:
RAPID REPEAT MEASUREMENT OF RCBF WITH PET AND 0-15 WATER
使用 PET 和 0-15 水快速重复测量 RCBF
- 批准号:
3774466 - 财政年份:
- 资助金额:
-- - 项目类别:
DESIGN OF FUNCTIONAL BRAIN MAPPING STUDIES WITH PET AND O15-WATER
使用 PET 和 O15-水进行脑功能图谱研究的设计
- 批准号:
5201148 - 财政年份:
- 资助金额:
-- - 项目类别:
OPTIMIZATION OF RCBF MEASUREMENT WITH A 3D PET SCANNER
使用 3D PET 扫描仪优化 RBF 测量
- 批准号:
5201149 - 财政年份:
- 资助金额:
-- - 项目类别:
A TRACER-KINETIC APPROACH TO ESTIMATE RADIATION DOSIMETRY OF 0-15 WATER
估算 0-15 水辐射剂量的示踪动力学方法
- 批准号:
3774468 - 财政年份:
- 资助金额:
-- - 项目类别:
OPTIMIZATION OF RCBF MEASUREMENT WITH A 3D PET SCANNER
使用 3D PET 扫描仪优化 RBF 测量
- 批准号:
3752240 - 财政年份:
- 资助金额:
-- - 项目类别:
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