ASSESSMENT OF PSYCHOLOGICAL ISSUES RELATED TO SUBSTANCE ABUSE TREATMENT

与药物滥用治疗相关的心理问题评估

• 批准号: 3752866
• 负责人: K L PRESTON
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3752866
• 关键词: behavior disorders; bioperiodicity; clinical trials; cocaine; correctional institutions; dreams; drug abuse therapy; drug addiction; human subject; human therapy evaluation; questionnaires; substance abuse related disorder; violence

The psychological assessment of subjects participating in clinical trials has become an important part of the section's research interest. Several studies were conducted: a comparison of drug abusers seeking treatment and not seeking treatment; an evaluation of personality disorders in cocaine dependent individuals seeking research treatment; and a survey of motivation for treatment. An important issue facing researchers and treatment providers is the reporting and representation of women and minorities in cocaine abuse pharmacotherapy clinical trials. Sociodemographic representation in 61 reports of outpatient pharmacotherapy for cocaine abuse, published in refereed, English language journals, between 1983 and 1993 was compared to the epidemiology of frequent cocaine use in the 1990 NIDA National Household Survey of Drug Abuse (NIDA-HS). The findings showed that important sociodemographic data is often not reported in papers, and raise issues of quality of research reports, generalizability of results, social equity, and accessibility for certain groups in cocaine abuse pharmacotherapy research. In procedural studies to identify improved outcome variable in clinical trials, the usefulness of quantitative urinalysis for cocaine metabolite and creatinine correction techniques and the relationship between these data and self-reported drug use were assessed with data collected in a clinical trial (N = 37) of a contingency management behavioral treatment intervention. Rules were developed to differentiate between occasions of new use and carry-over in positive qualitative urine tests. Preliminary analyses suggest: qualitative and quantitative urine testing show greater rates of drug use than that shown by self report; quantitative testing provides a means of differentiating incidences of new drug use from residual carry-over; the identification of new use with quantitative testing may help to reconcile differences between rates of drug use indicated by qualitative urine screens and self-report. Sweat patches have been proven effective in measuring cocaine and opiate use in controlled clinical laboratory settings but have not previously been tested under more realistic settings such as our treatment clinic. Collection of sweat as a method of monitoring drug use may be more accurate and reliable over a longer period of time than the urine testing method currently used. The purpose to evaluate the effectiveness of collecting sweat as an alternative method of monitoring drug use. Results will be compared to drug use as monitored by urine samples collected three times a week.

临床试验受试者的心理评估 已成为该科研究的一个重要部分。 几 进行了研究：寻求治疗的药物滥用者 而不寻求治疗;对人格障碍的评估， 寻求研究治疗的可卡因依赖者;以及一项调查 治疗的动机。 研究人员和治疗提供者面临的一个重要问题是， 妇女和少数群体滥用可卡因的报告和代表性 药物治疗临床试验。 61个国家的社会人口代表性 可卡因滥用的门诊药物治疗报告，发表于 本文对1983年和1993年的英文期刊进行了比较 在1990年NIDA全国流行病学调查中， 药物滥用家庭调查。 结果显示 重要的社会人口数据往往没有在论文中报告， 提出研究报告的质量、结果的普遍性、 社会公平和某些可卡因滥用群体的可获得性 药物治疗研究。 在手术研究中，确定临床中改善的结局变量 可卡因代谢物定量尿分析的实用性 和肌酸酐校正技术以及它们之间的关系 数据和自我报告的药物使用进行了评估，数据收集在一个 应急管理行为治疗的临床试验（N = 37） 干预 制定规则是为了区分不同的情况 新的使用和携带阳性定性尿液检测。 初步分析表明：定性和定量尿液检测 显示出比自我报告显示的更高的吸毒率; 定量测试提供了一种区分 残留结转中的新药物使用; 定量测试可能有助于调和 通过定性尿液筛查和自我报告表明药物使用。 汗液贴片已被证明在测量可卡因和鸦片制剂方面有效 在受控的临床实验室环境中使用，但之前没有 在更现实的环境下进行了测试，例如我们的治疗诊所。 收集汗液作为监测药物使用的方法可能更多 比尿检更长时间的准确和可靠 目前使用的方法。 评估有效性的目的 收集汗液作为监测药物使用的替代方法。 结果将与通过尿样监测的药物使用进行比较 每周收集三次。