Cryptococcal meningoencephalitis - fungal determinants of invasion of the CNS

隐球菌性脑膜脑炎 - 侵袭中枢神经系统的真菌决定因素

• 批准号: nhmrc : 1050106
• 负责人: A/Pr Julianne Djordjevic
• 金额: $ 39.18万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cryptococcal-meningoencephalitis-fungal-invasion-cns/112136
• 关键词: Cryptococcal; meningoencephalitis; fungal; determinants; invasion

Meningitis and brain infection (meningoencephalitis) due to the fungus Cryptococcus, affect over 1 million patients with AIDS annually, especially in developing countries; with more than 600,000 deaths. It is not known how Cryptococci cross from the blood stream into the brain; this must be elucidated in order to prevent and/or control this devastating infection. This project will determine how cryptococci influence host blood cells to act as “Trojan horses” and/or release products that initiate invasion of brain tissue and meningitis.

由真菌隐球菌引起的脑膜炎和脑感染（脑膜脑炎）每年影响100多万艾滋病患者，特别是在发展中国家；死亡人数超过60万。目前尚不清楚隐球菌是如何从血液进入大脑的；为了预防和/或控制这种毁灭性的感染，必须阐明这一点。该项目将确定隐球菌如何影响宿主血细胞充当“特洛伊木马”和/或释放产品，启动入侵脑组织和脑膜炎。