The fungal SEC14 secretory pathway and virulence

真菌 SEC14 分泌途径和毒力

• 批准号: nhmrc : 632634
• 负责人: A/Pr Julianne Djordjevic
• 金额: $ 35.76万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/fungal-sec14-secretory-pathway-virulence/82331
• 关键词: fungal; SEC14; secretory; pathway; virulence

Invasive fungal infections are a serious, escalating health issue. They cause severe disease with high death rates and are very costly to the health system. Current drugs often have suboptimal efficacy and cause side effects. New drugs are needed urgently. Many fungi, including the AIDS-related pathogen, Cryptococcus neoformans, secrete phospholipase B (Plbp) to facilitate infection. We will identify and investigate the Plbp secretion pathway as a novel anti-fungal drug target.

侵袭性真菌感染是一个严重的，不断升级的健康问题。它们造成严重的疾病，死亡率高，对卫生系统来说代价高昂。目前的药物往往疗效欠佳，并会引起副作用。急需新药。许多真菌，包括艾滋病相关的病原体，新型隐球菌，分泌磷脂酶B（Plbp），以促进感染。我们将确定和研究Plbp分泌途径作为一个新的抗真菌药物靶点。