Signalling pathways and fungal virulence – the inositol polyphosphate kinase pathway in Cryptococcus neoformans

信号通路和真菌毒力 — 新型隐球菌中的肌醇多磷酸激酶通路

• 批准号: nhmrc : 1058779
• 负责人: A/Pr Julianne Djordjevic
• 金额: $ 36.35万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-pathways-fungal-cryptococcus-neoformans/454703
• 关键词: Signalling; pathways; fungal; virulence; inositol

Bloodstream fungal infections kill millions of people per year world-wide and are costly to treat. A potentially fruitful strategy for developing new, urgently-needed drugs to fight these infections, is to target signalling pathways, which in fungi, are essential for establishing infection. This proposal investigates how one such pathway, the inositolpolyphosphate kinase pathway, allows fungi to establish infection and will determine which components are suitable targets for drug development.

血液真菌感染每年导致全世界数百万人死亡，治疗费用高昂。开发新的、迫切需要的药物来对抗这些感染的一个潜在的富有成效的策略是瞄准信号通路，这在真菌中是建立感染所必需的。本研究研究了肌醇多磷酸激酶途径如何允许真菌建立感染，并将确定哪些成分是药物开发的合适靶点。