IMPACT OF CALCIUM CHANNEL BLOCKER THERAPY IN PATIENTS WITH MICROVASCULAR ANGINA

我们以前曾报道过钙通道的症状益处 微血管性心绞痛（胸痛，正常）患者的阻滞剂治疗 冠状动脉造影，冠状动脉微血管收缩反应， 麦角新碱）。 为了评估钙通道阻滞剂的影响， 左心室功能，我们给了地尔硫卓，维拉帕米， 对14例血压正常伴静息异常的患者给予硝苯地平或尼卡地平治疗 和/或运动左心室功能（如评估的所有 放射性核素血管造影，并重复研究后3 几个月的钙通道阻滞剂 钙通道阻滞剂治疗 与全球和区域左 心室对运动的反应 我们的结论是钙通道 阻滞剂对微血管病变患者的左室功能有益 心绞痛和诱导性心肌缺血的证据，可能是由 改善运动应激期间的冠状动脉血流动力学。

We have previously reported the symptom benefit of calcium channel blocker therapy in patients with microvascular angina (chest pain, normal coronary angiograms, coronary microvascular constrictor response to ergonovine). In order to assess the impact of calcium channel blockers on left ventricular function, we administered diltiazem, verapamil, nifedipine, or nicardipine to 14 normotensive patients with abnormal rest and/or exercise left ventricular function (as assessed off all medications) by radionuclide angiography, and repeated studies after 3 months of calcium channel blockers. Calcium channel blocker therapy was associated with significant improvement in global and regional left ventricular responses to exercise. We conclude that calcium channel blockers benefit left ventricular function of patients with microvascular angina and evidence for inducible myocardial ischemia, probably by improving coronary flow dynamics during exercise stress.