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IMPACT OF CALCIUM CHANNEL BLOCKER THERAPY IN PATIENTS WITH MICROVASCULAR ANGINA

IMPACT OF CALCIUM CHANNEL BLOCKER THERAPY IN PATIENTS WITH MICROVASCULAR ANGINA
钙通道阻滞剂治疗对微血管心绞痛患者的影响
批准号：
3779620
负责人：
R O CANNON
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3779620
关键词：
angina pectoris angiocardiography calcium channel blockers diltiazem heart circulation heart disorder chemotherapy heart function heart ventricle human subject human therapy evaluation microcirculation myocardial ischemia /hypoxia nicardipine nifedipine radiodiagnosis verapamil

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英文摘要
We have previously reported the symptom benefit of calcium channel blocker therapy in patients with microvascular angina (chest pain, normal coronary angiograms, coronary microvascular constrictor response to ergonovine). In order to assess the impact of calcium channel blockers on left ventricular function, we administered diltiazem, verapamil, nifedipine, or nicardipine to 14 normotensive patients with abnormal rest and/or exercise left ventricular function (as assessed off all medications) by radionuclide angiography, and repeated studies after 3 months of calcium channel blockers. Calcium channel blocker therapy was associated with significant improvement in global and regional left ventricular responses to exercise. We conclude that calcium channel blockers benefit left ventricular function of patients with microvascular angina and evidence for inducible myocardial ischemia, probably by improving coronary flow dynamics during exercise stress.
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