ABNORMAL ESOPHAGEAL MOTILITY IN PATIENTS WITH LIMITED CORONARY FLOW RESERVE

冠状动脉血流储备有限患者的食管运动异常

• 批准号: 3966721
• 负责人: R O CANNON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3966721
• 关键词: angina pectoris; angiography; coronary artery; dipyridamole; electronic pacemaker; esophagus motility /pressure; gastrointestinal pharmacology; heart circulation; human subject; vascular resistance; vasoconstriction

Explanations for chest pain in patients with chest pain, despite angiographically normal coronary arteries include abnormal coronary flow reserve and esophageal motility disorders. To ascertain the frequency of cardiac versus esophageal functional abnormalities in such patients, 43 patients with chest pain despite normal epicardial coronary arteries underwent measurement of coronary resistance during pacing at a heart rate of 150, heart rate of 150 after ergonovine, 0.5-0.3 mg intravenously and after dipyridamole 0.5-0.75 mg/kg intravenously. Those patients who had dynamic limitation in flow reserve to ergonovine and limited flow reserve after dipyridamole had a higher prevalence of esophageal motility disorders than those patients who had no vasoconstrictor response to ergonovine and had a normal flow reserve after dipyridamole. The high prevalence of abnormal esophageal motility in patients with dynamic limitation in coronary flow reserve suggests that this syndrome may be part of a generalized abnormality of smooth muscle rectivity.

胸痛患者胸痛的解释，尽管 冠状动脉造影术正常的冠状动脉包括异常的冠状动脉血流 储备和食道动力障碍。确定……的频率 此类患者的心脏和食道功能异常，43例 尽管心外膜冠状动脉正常但仍有胸痛的患者 以心率起搏时测量冠脉阻力 150，麦角新碱后心率150，静脉注射0.5-0.3毫克， 双嘧达莫0.5-0.75 mg/kg后静脉注射。那些曾经的病人 动态流量储备对麦角新的限制和流量储备的限制 潘生丁治疗后有较高的食道动力障碍患病率 比那些对麦角新无血管收缩反应的患者和 潘生丁治疗后血流储备正常。艾滋病的高流行率 动态受限患者的食道动力异常 冠脉血流储备提示这种综合征可能是 全身性肌电活动异常。