HYPERINSULINEMIA IN PATIENTS WITH CHEST PAIN AND NORMAL CORONARY ARTERIES
HYPERINSULINEMIA IN PATIENTS WITH CHEST PAIN AND NORMAL CORONARY ARTERIES
批准号:
3858136
负责人:
R O CANNON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
中文摘要
最近有报道称,胰岛素对葡萄糖负荷的反应过多
X综合征患者(劳力性心绞痛,缺血性ST段反应
运动,正常的冠状动脉)。评估艾滋病的流行率
高胰岛素血症对非糖尿病胸腔积液患者血管的影响
疼痛综合征和血管造影正常的冠状动脉,我们测量了
65例患者和16例健康体检者的血浆胰岛素水平
年龄、性别和体重。在34名患者和对照组的子组中,前臂
用阻抗体积描记法测量血管阻力。虽然
胸痛和胸痛患者的空腹胰岛素水平相似
冠状动脉造影术正常的患者和对照组
显著更高的峰值胰岛素应答(153/-77比87/-40(MU)U/ml,
P>;0.01)至葡萄糖75克。基线和前臂缺血后5分钟
对照组的血管阻力在治疗前和治疗前相似。
胸痛患者在高胰岛素血症情况下的糖负荷后
血管造影术显示冠状动脉正常。在这些患者中,
胸痛与冠状动脉正常之间无相关性
高胰岛素血症的存在和严重程度,以及
高血压、冠脉微血管功能障碍、微血管收缩
对麦角新碱的反应)或对运动的心电图反应。因此,虽然
高胰岛素血症在胸痛患者中很常见,无论
运动对EKG的反应,胰岛素水平升高对
冠状动脉和全身血管系统尚不清楚。
英文摘要
Excess insulin responses to glucose load have recently been reported in
patients with syndrome X (effort angina, ischemic-appearing ST responses
to exercise, normal coronary arteries). To assess the prevalence in
vascular effects of hyerinsulenemia in non-diabetic patients with chest
pain syndromes and angiographically normal coronary arteries, we measured
plasma insulin levels in 65 patients and 16 healthy controls of similar
age, gender and weight. In a subset of 34 patients and controls, forearm
vascular resistance was measured by impedance plethysmography. Although
fasting insulin levels were similar for the patients with chest pain and
angiographically normal coronary arteries and controls, patients had
significantly higher peak insulin responses (153/-+77 vs 87/-+40 (mu)U/ml,
p>0.01) to glucose 75 gm. Baseline and 5 minute post-ischemic forearm
vascular resistances were similar for controls in patients both before and
after glucose load despite hyperinsulemneia in the patients with chest pain
and angiographically normal coronary arteries. Among the patients with
chest pain and normal coronary arteries there was no correlation between
the presence and severity of hyperinsulenemia, and the presence of
hypertension, coronary microvascular dysfunction microvascular constrictor
response to ergonovine) or EKG responses to exercise. Thus, although
hyperinsulenemia is common in patients with chest pain regardless of the
EKG response to exercise, the impact of increased insulin levels on the
coronary and systemic vasculature is unclear.
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会议论文
EFFECT OF SURGICAL RELIEF OF OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY
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批准号:4694686
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
HORMONE THERAPY AND INFLAMMATORY CELL ADHESION MOLECULES
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批准号:6109271
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
ABNORMAL ESOPHAGEAL MOTILITY IN PATIENTS WITH LIMITED CORONARY FLOW RESERVE
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批准号:3966721
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
DETRIMENTAL EFFECT OF ERGONOVINE IN HYPERTROPHIC CARDIOMYOPATHY
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批准号:4694671
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
SYSTEMIC VASCULAR EFFECTS OF 17 BETA-ESTRADIOL IN POSTMENOPAUSAL WOMEN
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批准号:3757704
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
ANTIOXIDANT VITAMINS, LIPOPROTEIN OXIDATION & VASOMOTION IN HYPERCHOLESTEROLEMIA
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批准号:3757713
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
MYOCARDIAL ISCHEMIA AND HYPERTROPHIC CARDIOMYOPATHY
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批准号:3858114
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
CORONARY FLOW RESERVE AND ABNORMAL LEFT VENTRICULAR RESPONSE TO EXERCISE
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批准号:3843398
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
ABNORMAL BRONCHIAL AIRWAY FUNCTION IN PATIENTS WITH MICROVASCULAR ANGINA
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批准号:3920210
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
EFFECT OF LIDOFLAZINE ON EXERCISE TOLERANCE IN MICROVASCULAR ANGINA
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批准号:3942959
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
EFFECT OF SURGICAL RELIEF OF OBSTRUCTION IN HYPERTROPHIC CARDIOMYOPATHY
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批准号:3942929
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
EFFECT OF LIDOFLAZINE ON CORONARY FLOW RESERVE
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批准号:3942960
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项目类别:
-
资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
CORONARY FLOW RESERVE IN DILATED CARDIOMYOPATHY
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批准号:3942931
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
"FALSE POSITIVE" RADIONUCLIDE ANGIOGRAPHIC STUDIES IN WOMEN WITH CHEST PAIN
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批准号:3843397
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
ESTROGEN AND VITAMIN E EFFECTS ON LIPOPROTEIN OXIDATION IN POSTMENOPAUSAL WOMEN
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批准号:3757714
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
EFFECTS OF SURGERY FOR HYPERTROPHIC CARDIOMYOPATHY ON EXERCISE HEMODYNAMICS
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批准号:3899262
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
DETRIMENTAL EFFECT OF ERGONOVINE IN HYPERTROPHIC CARDIOMYOPATHY
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批准号:3966699
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
SUPRAVENTRICULAR TACHYCARDIA AND SYNCOPE IN HYPERTROPIC CARDIOMYOPATHY
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批准号:3966725
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
CORONARY FLOW RESERVE ARE AFTER DIPYRIDAMOLE
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批准号:4694684
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
INVESTIGATION OF MYOCARDIAL ISCHEMIA IN HYPERTROPHIC CARDIOMYOPATHY
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批准号:4694685
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项目类别:
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资助金额:$0.0万
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财政年份:--
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负责人:R O CANNON
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依托单位:
海外基金