HYPERINSULINEMIA IN PATIENTS WITH CHEST PAIN AND NORMAL CORONARY ARTERIES

胸痛且冠状动脉正常的患者出现高胰岛素血症

• 批准号: 3858136
• 负责人: R O CANNON
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3858136
• 关键词: angina pectoris; angiography; coronary artery; electrocardiography; exercise; human subject; hyperinsulinism; hypertension; microcirculation; myocardial ischemia /hypoxia; plethysmography; vascular resistance

Excess insulin responses to glucose load have recently been reported in patients with syndrome X (effort angina, ischemic-appearing ST responses to exercise, normal coronary arteries). To assess the prevalence in vascular effects of hyerinsulenemia in non-diabetic patients with chest pain syndromes and angiographically normal coronary arteries, we measured plasma insulin levels in 65 patients and 16 healthy controls of similar age, gender and weight. In a subset of 34 patients and controls, forearm vascular resistance was measured by impedance plethysmography. Although fasting insulin levels were similar for the patients with chest pain and angiographically normal coronary arteries and controls, patients had significantly higher peak insulin responses (153/-+77 vs 87/-+40 (mu)U/ml, p>0.01) to glucose 75 gm. Baseline and 5 minute post-ischemic forearm vascular resistances were similar for controls in patients both before and after glucose load despite hyperinsulemneia in the patients with chest pain and angiographically normal coronary arteries. Among the patients with chest pain and normal coronary arteries there was no correlation between the presence and severity of hyperinsulenemia, and the presence of hypertension, coronary microvascular dysfunction microvascular constrictor response to ergonovine) or EKG responses to exercise. Thus, although hyperinsulenemia is common in patients with chest pain regardless of the EKG response to exercise, the impact of increased insulin levels on the coronary and systemic vasculature is unclear.

最近有报道称，胰岛素对葡萄糖负荷的反应过多 X综合征患者(劳力性心绞痛，缺血性ST段反应 运动，正常的冠状动脉)。评估艾滋病的流行率 高胰岛素血症对非糖尿病胸腔积液患者血管的影响 疼痛综合征和血管造影正常的冠状动脉，我们测量了 65例患者和16例健康体检者的血浆胰岛素水平 年龄、性别和体重。在34名患者和对照组的子组中，前臂 用阻抗体积描记法测量血管阻力。虽然 胸痛和胸痛患者的空腹胰岛素水平相似 冠状动脉造影术正常的患者和对照组 显著更高的峰值胰岛素应答(153/-+77比87/-+40(亩)U/ml， P&gt；0.01)至葡萄糖75克。基线和前臂缺血后5分钟 对照组的血管阻力在治疗前和治疗前相似。 胸痛患者在高胰岛素血症情况下的糖负荷后 血管造影术显示冠状动脉正常。在这些患者中， 胸痛与冠状动脉正常之间无相关性 高胰岛素血症的存在和严重程度，以及 高血压、冠脉微血管功能障碍、微血管收缩 对麦角新碱的反应)或对运动的心电图反应。因此，虽然 高胰岛素血症在胸痛患者中很常见，无论 运动对EKG的反应，胰岛素水平升高对 冠状动脉和全身血管系统尚不清楚。