MH-CRC: NEUROBIOLOGY & PHENOMENOLOGY OF MAJOR PSYCHOSES

MH-CRC：神经生物学

• 批准号: 3107205
• 负责人: NANCY C ANDREASEN
• 金额: $ 148.28万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3107205
• 关键词: human subject; mental disorder chemotherapy; mental disorder diagnosis; neurobiology; schizophrenia

This MH-CRC has as its major emphasis the study of schizophrenia and related spectrum disorders. Its unifying concept is the goal of linking the clinical picture of the illness with its underlying neurobiology. The MH-CRC is composed of seven research units. These units conduct the integrative and interdisciplinary research that is needed to advance our knowledge concerning the clinical presentation of schizophrenia and its relation to pathophysiology, etiology, prevention and treatment. The Diagnosis and the Phenomenology Unit examines clinical issues, including evaluation, nosology, longitudinal outcome, and instrument development. The Brain Imaging Unit focuses on structural and functional brain abnormalities, using CT scanning, MRI, and SPECT; these studies attempt to integrate our understanding of the clinical symptoms, such as hallucinations, with the neural mechanisms that underlie them. The Genetics Unit takes a comprehensive approach to the genetics of schizophrenia, using multiplex family studies, twin studies, adoption studies, and molecular genetics. Multiple biological measures are obtained in order to identify markers. The Epidemiology Unit explores mortality in schizophrenia, birth history and other risk factors; this unit works closely with the Genetics unit in order to examine the environmental side of the genetic versus environmental interaction. The Basic Neurobiology Unit conducts research on animal models of psychosis and neurotransmitter systems assessed using both central and peripheral measures. The Neuropharmacology Unit pursues the study of pharmacokinetics, drug dosage, target symptoms, and side effects. The Neurophysiology/Neuropsychology Unit examines cognitive processing in psychosis and conducts studies using a variety of electrophysiological techniques. Three core units support these research units: Administrative, Assessment and Training, and Biostatistics. The Administrative Core Unit is responsible for maintaining a five-to six- bed inpatient unit on which patients can be studied after a three-week medication washout, as well as while on medications. This inpatient unit is crucial to the conduct of a majority of studies conducted by the MH-CRC, since an important goal is establishing the validity of neurobiological measures without contamination by neuroleptic effects. The Assessment and Training Unit insures that all assessment procedures are conducted in a reliable manner and provides training to investigators at Iowa and visitors from other facilities. The Biostatistics Core Unit maintains rigorous quality control over data management and provides consultation to investigators on experimental design and data analysis.

该MH-CRC的主要重点是精神分裂症的研究， 相关的谱系障碍。 它的统一概念是连接 疾病的临床表现及其潜在的神经生物学。 MH-CRC由七个研究单位组成。 这些单位进行 综合和跨学科的研究，需要推进我们的 精神分裂症的临床表现及其 与病理生理、病因、预防和治疗的关系。 的 诊断和现象学单位检查临床问题，包括 评估、疾病分类学、纵向结果和工具开发。 脑成像单元侧重于结构和功能的大脑 异常，使用CT扫描，MRI和SPECT;这些研究试图 整合我们对临床症状的理解，例如 幻觉和它们背后的神经机制 的 遗传学股采取全面的方法，以遗传学的 精神分裂症，多重家系研究，双生子研究，收养 研究和分子遗传学。 获得了多种生物学措施， 以识别标记。 流行病学股探讨死亡率， 精神分裂症，出生史和其他危险因素;这个单位的工作 与遗传学单位密切合作，以检查环境方面 基因与环境的相互作用。 基础神经生物学 单位进行精神病和神经递质的动物模型研究 使用中央和外围措施评估系统。 的 神经药理学单位从事药代动力学，药物剂量， 针对症状和副作用 神经生理学/神经心理学 单位检查精神病的认知过程，并使用 各种电生理技术。 三个核心单元支持 这些研究单位：行政，评估和培训，以及 生物统计学。 行政核心股负责维持一个五至六人的 病床住院单位，病人可以在三周后进行研究 药物洗脱，以及在药物治疗期间。 这个住院部 对MH-CRC进行的大多数研究至关重要， 因为一个重要的目标是建立神经生物学的有效性， 不受精神抑制剂影响的措施。 评估和 培训股确保所有评估程序都以 可靠的方式，并提供培训，以调查人员在爱荷华州和游客 其他设施。 生物统计学核心单元保持严格的 质量控制数据管理，并提供咨询， 实验设计和数据分析。