CENTER OF EXCELLENCE IN MOLECULAR HEMATOLOGY

血细胞研究的最新进展使表征成为可能。 影响血细胞的正常和突变基因， 这些疾病的新的和具体的治疗方法的机会。继续 要取得进展，需要开发更先进的分子生物学技术。 技术和高度组织化的行政结构来协调 复杂疗法的临床实施， 诸如供体获取、基因转移和骨髓移植等程序 移植从科学上讲，非常需要一种有效的 提供共享资源和通信的基础设施 研究人员在这一领域的工作，使快速进展， 实验室到床边杜克大学医学中心和 北卡罗来纳州大学最近做出了重大努力， 招募和发展能够使重要的研究人员， 与分子诊断、分子分析和 血液病的分子治疗。 我们建议设计和 实施分子血液学卓越中心， 合并两个机构的资源，作为活动重点 在分子血液学中。 该中心将帮助确定重要需求 对于研究血液学问题的研究者，将提供共享的 资源，并将通过有效的沟通促进互动。 私人和公共机构的参与， 血液学程序位于密切接近应公关？vide一个独特的 有机会在分子血液学发展一个杰出的计划， 为其他中心的设计做出贡献。

Recent advances in blood cell research have enabled the characterization of normal and mutant genes affecting blood cells and has provided the opportunity for novel and specific therapies for these diseases. Continued progress will require the development of more advanced molecular techniques and highly organized administrative structures to coordinate the clinical implementation of complex therapies that may involve procedures such as donor procurement, gene transfer, and bone marrow transplantation. scientifically there is a great need for an effective infrastructure to provide shared resources and communication among investigators working in this field to allow rapid progress from the laboratory to the bedside. Duke University Medical Center and the University of North Carolina have recently undertaken major efforts to recruit and develop investigators who will be able to make important discoveries related to the molecular diagnosis, molecular analysis, and molecular treatment of hematologic diseases. We propose to design and implement a Center of Excellence in Molecular Hematology that will use the combined resources of the two institutions to serve as a focus of activity in molecular hematology. This Center will help identify important needs for investigators working on problems in hematology, will provide shared resources, and will foster interactions through effective communication. The participation of a private and public institution with complementing hematology programs located in close proximity should pr?vide a unique opportunity to develop an outstanding program in Molecular Hematology and to contribute to the design of additional Centers.