TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF ZIDOVUDINE (AZT) IN CHILDREN

评估齐多夫定 (AZT) 对儿童的安全性和有效性的试验

• 批准号: 3784599
• 负责人: NANCY HUTTON
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3784599
• 关键词: AIDS dementia complex; AIDS therapy; HIV infections; child (0-11); clinical trials; dosage; drug adverse effect; drug screening /evaluation; drug tolerance; human subject; human therapy evaluation; longitudinal human study; pathologic process; pediatric AIDS; zidovudine

This is a Phase III trial of high versus low dose zidovudine administered to children with symptomatic HIV infection. Treatment will continue until the last patient enrolled has received 104 weeks, and direct assessments will be made for tolerance and side effects of the two regimens, for the progression of HIV infection, and for the degree of change in neurodevelopmental disease. Comparisons will be made between groups for clinical, immunological, and virological parameters.

这是一项高剂量与低剂量齐多夫定的三期试验