EFFECTS OF DIETARY CHOLESTEROL AND SATURATED FAT ON LDL RECEPTOR ACTIVITY

膳食胆固醇和饱和脂肪对 LDL 受体活性的影响

• 批准号: 3786498
• 负责人: WILLIAM E. CONNOR
• 金额: --
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3786498
• 关键词: blood lipoprotein metabolism; cholesterol; diet therapy; dietary lipid; familial hyperlipoproteinemia type II; human subject; human therapy evaluation; lovastatin; low density lipoprotein; metabolism disorder chemotherapy; nutrient drug interaction; nutrition related tag; receptor expression; saturated fatty acids

This study examines the influence of regulating dietary cholesterol and saturated fats on LDL receptor activity in patients with familial hypercholesterolemia who are being treated with mevinolin. The effects of dietary intervention are evaluated by measurement of total plasma cholesterol and LDL as well as LDL turnover.

这项研究探讨了调节膳食胆固醇和 饱和脂肪对家族性心脏病患者 LDL 受体活性的影响 正在接受美维诺林治疗的高胆固醇血症。 效果 通过测量总血浆来评估饮食干预的效果 胆固醇和低密度脂蛋白以及低密度脂蛋白周转率。